Table 4.
Distribution of signal values of the first 30 PTs.
| PT | ROR (95% CI) | PRR (X2) | MGPS (95% CI lower) | BCPNN (95% CI lower) | Capecitabine | All reports | p Value |
|---|---|---|---|---|---|---|---|
| Diarrhea | 5.26 (5.13–5.39) | 5.04 (21,241.3) | 4.99 (4.88) | 2.32 (0.65) | 6578 | 122,826 | <0.001 |
| Nausea | 2.73 (2.65–2.81) | 2.67 (4636.55) | 2.66 (2.59) | 1.41 (−0.26) | 4416 | 124,988 | <0.001 |
| Palmar-plantar erythrodysaesthesia syndrome | 103.86 (100.25–107.59) | 100.7 (311,968.28) | 80.26 (77.92) | 6.33 (4.66) | 3974 | 125,430 | <0.001 |
| Fatigue | 2.14 (2.07–2.22) | 2.11 (2006.7) | 2.11 (2.05) | 1.07 (−0.59) | 3402 | 126,002 | <0.001 |
| Vomiting | 3.02 (2.91–3.13) | 2.97 (3787.86) | 2.96 (2.87) | 1.57 (−0.1) | 2890 | 126,514 | <0.001 |
| Decreased appetite | 2.92 (2.77–3.07) | 2.9 (1810.03) | 2.88 (2.76) | 1.53 (−0.14) | 1461 | 127,943 | <0.001 |
| Dehydration | 4.93 (4.67–5.2) | 4.89 (4271.01) | 4.84 (4.63) | 2.27 (0.61) | 1396 | 128,008 | <0.001 |
| Neuropathy peripheral | 6.47 (6.11–6.85) | 6.42 (5505.09) | 6.33 (6.04) | 2.66 (1) | 1221 | 128,183 | <0.001 |
| Stomatitis | 9.44 (8.9–10.02) | 9.37 (8335.97) | 9.17 (8.73) | 3.2 (1.53) | 1141 | 128,263 | <0.001 |
| Neutropenia | 4.14 (3.9–4.4) | 4.12 (2614.76) | 4.08 (3.89) | 2.03 (0.36) | 1118 | 128,286 | <0.001 |
| Skin exfoliation | 5.65 (5.3–6.04) | 5.62 (3445.4) | 5.55 (5.26) | 2.47 (0.81) | 919 | 128,485 | <0.001 |
| Thrombocytopenia | 3.98 (3.73–4.25) | 3.96 (1999.86) | 3.93 (3.72) | 1.97 (0.31) | 912 | 128,492 | <0.001 |
| Mucosal inflammation | 17.41 (16.28–18.61) | 17.29 (13,235.6) | 16.6 (15.7) | 4.05 (2.39) | 900 | 128,504 | <0.001 |
| Dry skin | 3.24 (3.02–3.47) | 3.22 (1236.21) | 3.21 (3.02) | 1.68 (0.01) | 811 | 128,593 | <0.001 |
| Paraesthesia | 2.34 (2.19–2.51) | 2.33 (611.32) | 2.33 (2.2) | 1.22 (−0.45) | 804 | 128,600 | <0.001 |
| Skin discoloration | 8.05 (7.49–8.64) | 8 (4645.64) | 7.86 (7.41) | 2.98 (1.31) | 773 | 128,631 | <0.001 |
| Hypoesthesia | 2.21 (2.06–2.38) | 2.21 (472.26) | 2.2 (2.07) | 1.14 (−0.53) | 717 | 128,687 | <0.001 |
| Febrile neutropenia | 3.88 (3.56–4.23) | 3.87 (1082.08) | 3.84 (3.57) | 1.94 (0.28) | 513 | 128,891 | <0.001 |
| Platelet count decreased | 2.29 (2.1–2.5) | 2.28 (367.49) | 2.28 (2.12) | 1.19 (−0.48) | 512 | 128,892 | <0.001 |
| White blood cell count decreased | 2.22 (2.03–2.42) | 2.22 (335.81) | 2.21 (2.05) | 1.14 (−0.52) | 505 | 128,899 | <0.001 |
| Leukopenia | 4.77 (4.36–5.21) | 4.76 (1439.94) | 4.71 (4.37) | 2.24 (0.57) | 491 | 128,913 | <0.001 |
| Blister | 4.06 (3.7–4.45) | 4.04 (1039.98) | 4.01 (3.72) | 2 (0.34) | 458 | 128,946 | <0.001 |
| Bone marrow failure | 7.76 (6.99–8.6) | 7.74 (2094.29) | 7.61 (6.97) | 2.93 (1.26) | 364 | 129,040 | <0.001 |
| Skin fissures | 11.95 (10.76–13.27) | 11.92 (3514.84) | 11.6 (10.62) | 3.54 (1.87) | 362 | 129,042 | <0.001 |
| Intestinal obstruction | 4.42 (3.96–4.93) | 4.41 (849.9) | 4.37 (3.99) | 2.13 (0.46) | 326 | 129,078 | <0.001 |
| Myelosuppression | 8.37 (7.49–9.36) | 8.35 (2022.41) | 8.2 (7.47) | 3.04 (1.37) | 319 | 129,085 | <0.001 |
| Hepatic function abnormal | 4.18 (3.74–4.68) | 4.17 (743.17) | 4.14 (3.77) | 2.05 (0.38) | 311 | 129,093 | <0.001 |
| Hypokalemia | 3.21 (2.87–3.59) | 3.2 (459.87) | 3.18 (2.9) | 1.67 (0) | 306 | 129,098 | <0.001 |
| Colitis | 4.08 (3.64–4.57) | 4.08 (694.03) | 4.04 (3.68) | 2.02 (0.35) | 302 | 129,102 | <0.001 |
| Arteriospasm coronary | 41.03 (36.38–46.26) | 40.94 (10,403.24) | 37.15 (33.6) | 5.22 (3.55) | 295 | 129,109 | <0.001 |
BCPNN, Bayesian confidence propagation neural network; MGPS, multi-item gamma Poisson shrinker; PRR, proportional reporting ratio; PT, preferred term; ROR, reporting odds ratio.