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. Author manuscript; available in PMC: 2024 Dec 20.
Published in final edited form as: Nat Rev Nephrol. 2024 Apr 17;20(7):447–459. doi: 10.1038/s41581-024-00834-0

Fig. 5. Potential models for epithelial injury after TCMR or ABMR.

Fig. 5

Epithelial injury occurs in, both, TCMR and ABMR. As epithelial injury is the most important predictor of allograft survival after ABMR or TCMR, this might suggest a model of persistence of maladaptive injured epithelial cells propagating further kidney allograft damage. Importantly, whether maladaptive or injured epithelial cell states persisting after ABMR or TCMR are identical or distinct remains unknown.