Table 2.
Associations of triglyceride-glucose index and remnant cholesterol with stroke risk.
| Variables | No. of event/total | Model 1a | Model 2b | Model 3c | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
| TyG index | |||||||
| Quartile | |||||||
| Q1 [5.18, 8.25] | 122/2,643 | Reference | Reference | Reference | |||
| Q2 (8.25, 8.62] | 163/2,642 | 1.36 (1.07–1.72) | 0.011 | 1.31 (1.03–1.65) | 0.026 | 1.26 (1.00–1.60) | 0.051 |
| Q3 (8.62, 9.07] | 210/2,642 | 1.76 (1.41–2.21) | <0.001 | 1.58 (1.26–1.98) | <0.001 | 1.43 (1.14–1.80) | 0.002 |
| Q4 (9.07, 12.3] | 239/2,642 | 2.06 (1.65–2.56) | <0.001 | 1.76 (1.40–2.20) | <0.001 | 1.46 (1.16–1.85) | 0.002 |
| Per-1-SD increase | 734/10,569 | 1.29 (1.21–1.38) | <0.001 | 1.22 (1.14–1.31) | <0.001 | 1.14 (1.06–1.23) | 0.001 |
| Remnant cholesterol | |||||||
| Quartile | |||||||
| Q1 [0.39, 12.00] | 139/2,647 | Reference | Reference | Reference | |||
| Q2 (12.00, 20.10] | 180/2,643 | 1.35 (1.08–1.68) | 0.008 | 1.29 (1.03–1.61) | 0.026 | 1.25 (1.00–1.56) | 0.052 |
| Q3 (20.10, 32.10] | 174/2,642 | 1.31 (1.05–1.64) | 0.018 | 1.20 (0.96–1.51) | 0.104 | 1.14 (0.91–1.43) | 0.252 |
| Q4 (32.10, 195.00] | 241/2,637 | 1.88 (1.52–2.31) | <0.001 | 1.61 (1.30–1.99) | <0.001 | 1.45 (1.17–1.80) | 0.001 |
| Per-1-SD increase | 734/10,569 | 1.19 (1.13–1.26) | <0.001 | 1.14 (1.07–1.21) | <0.001 | 1.09 (1.02–1.16) | 0.006 |
CI, confidence interval; HR, hazard ratio; SD, standard deviation; TyG, triglyceride-glucose; Q, quartile.
a
Adjusted for age and gender.
b
Adjusted for age, gender, marital status, residence, education level, body mass index, smoking status, and drinking status.
c
Adjusted as model 2 plus diabetes, hypertension, heart disease, dyslipidemia, kidney disease, history of medication use for diabetes, history of medication use for hypertension, history of medication use for dyslipidemia, systole blood pressure, diastolic blood pressure, HbA1c, hsCRP, and eGFR.