Table 2.

Metabolic pathways of distinct compounds in recurrence model group and normal control group.

Pathway	Pathway impact factor	p	Up	Down
Neomycin, kanamycin and gentamicin biosynthesis	1.00	1.85e-03	D-Glucose; glucose 6-phosphate
Valine, leucine and isoleucine biosynthesis	0.25	3.73e-03	Ketoleucine	L-leucine; L-valine
Alanine, aspartate and glutamate metabolism	0.26	5.95e-03	Citric acid; gamma-aminobutyric acid; L-alanine	L-asparagine; L-glutamine
Arginine biosynthesis	0.12	2.01e-02	Citrulline	L-glutamine; urea
Galactose metabolism	0.03	2.67e-02	D-galactose; D-glucose; D-mannose; myoinositol
Taurine and hypotaurine metabolism	0.33	4.38e-02	Hypotaurine; taurine	Taurine and hypotaurine metabolism
Valine, leucine and isoleucine degradation	0.08	0.091	Ketoleucine; methylmalonic acid	L-leucine; L-valine
Purine metabolism	0.04	0.161	Allantoic acid; guanine	Guanosine; L-glutamine; urea