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. 2025 Jan 1;16(1):183–200. doi: 10.7150/jca.102180

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Development of PANoptosis-related prognostic models for EAC patients within the TCGA/GTEx cohorts. (A, B) LASSO coefficient profiles and penalty plots for the model incorporating 18 prognostic genes. (C)Univariate Cox regression analysis forest plots correlating 8 prognostic-related DEPRGs with overall survival (OS). (D) Principal component analysis (PCA) differentiating high- and low-risk groups in the TCGA cohort. (E) Kaplan-Meier (KM) survival curves comparing OS among patients in the two risk groups. (F) Distributions of risk (high or low), survival status of EAC patients, and expression levels of eight risk genes associated with PANoptosis. (G) Receiver operating characteristic (ROC) curves evaluating the predictive accuracy of the risk score within the TCGA cohort. (H) Outcomes of multivariate Cox regression analysis of OS to assess the prognostic independence of the risk score.