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. 2025 Jan 1;16(1):183–200. doi: 10.7150/jca.102180

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MMP12 Expression and Functional Analysis in EAC Cells, with Associated Drug Sensitivity Studies. (A) qPCR analysis of MMP12 expression in normal esophageal cells (HET-1A), well-differentiated EAC cell line (SKGT-4), and poorly differentiated EAC cell line (OE19). (B, C) Knockdown and overexpression of MMP12 confirmed by quantitative RT-PCR (b) and Western blotting (WB) (c) in SKGT-4 and OE19 cells, respectively (*p < 0.05; **p < 0.01; ***p < 0.001). (D) Cell proliferation of MMP12-knockdown EAC cells assessed by CCK-8 assays. (E, F) Motility of MMP12-knockdown and overexpressed EAC cells evaluated using wound healing assays (E) and Transwell invasion assays (F). (G) Box-violin plots illustrating lower IC50 values for three drugs in high-risk groups, suggesting increased drug sensitivity.