Figure 1. IL1RAP is broadly expressed in pancreatic tumors. (A) Gene expression data from GTEx and TCGA public datasets, comparing gene expression in normal pancreatic tissue (N=167) with pancreatic ductal adenocarcinoma (PDAC) tumors (N=150). (B) Survival analysis of PDAC patients grouped by median IL1RAP expression in the Know Your Tumor data set. (C–E) IHC stains for IL-1α, IL-1β, and IL1RAP in a PDAC tumor, showing expression on cancer cells (left images), cancer-associated fibroblasts (CAFs) (middle images), and immune cells (right images). The images shown are representative stains out of five tumors tested. A 2.5× magnification of selected cells is shown in the upper right corner. Significance calculated by Mann-Whitney test in (A) and by Log-rank (Mantel-Cox) test in (B). Significance levels are indicated as ****p<0.0001. IHC, Immunohistochemistry.