Table 1.
Demographic, clinical, and neuropathologic characteristics of study participants stratified by clinical diagnosis and presence or absence of Lewy pathology
| Lewy Pathology (n = 597) |
No Lewy Pathology (n = 491) |
p-value | ||
|---|---|---|---|---|
| Sex (Female %) | 38.7% | 41.8% | 0.34 | |
| Age (Years) | 75 [68–80] | 74 [67–78] | 0.19 | |
| Education (Years) | 16 [14–18] | 16 [13–18] | 0.013 | |
| APOE ε4 (%) | 52% | 52.5% | 0.91 | |
| Clinical Diagnosis (%) | CN | 21.8% | 21.8% | 0.054 |
| MCI | 26.1% | 20.2% | ||
| Dementia | 52.1% | 58% | ||
| Final diagnosis of LBD (%) | 22.8% | 3.9% | < 0.0001 | |
| Tau NFT (%) | Braak 0-II | 15.4% | 8.4% | 0.0006 |
| Braak III-IV | 24.8% | 19.1% | ||
| Braak V-VI | 59.8% | 72.5% | ||
| Lewy Pathology (%) | Limbic | 40.5% | 0% | NA |
| Neocortical | 59.5% | 0% | ||
CN: Cognitively Normal; LBD: Lewy Body Dementia; MCI: Mild Cognitive Impairment; NFT: Neurofibrillary Tangles. The median (25th and 75th percentiles) was provided for age and education