Table 2.
Survival models. Prediction of clinical progression in Cox hazards models
| With APOE | CN to MCI/Dementia | |||
|---|---|---|---|---|
| All | Exclude Braak V-VI (n = 147) | |||
| Variable | HR (95% CI) | Pr(>|z|) | HR (95% CI) | Pr(>|z|) |
| Sex (Male) | 1.0 [0.70–1.42] | 0.99 | 1.05 [0.65–1.70] | 0.84 |
| Age (years) | 0.99 [0.96–1.02] | 0.57 | 1 [0.97–1.05] | 0.78 |
| Education (yrs) | 0.99 [0.93–1.06] | 0.80 | 0.98 [0.9–1.07] | 0.62 |
| NFT Braak III-IV | 1.30 [0.77–2.20] | 0.33 | 1.18 [0.69–2.04] | 0.55 |
| NFT Braak V-VI | 1.98 [1.19–3.29] | 0.009 | - | - |
| Limbic LP | 0.74 [0.47–1.16] | 0.19 | 1.04 [0.57–1.9] | 0.91 |
| Neocortical LP | 1.34 [0.88–2.05] | 0.17 | 1.74 [0.96–3.1] | 0.068 |
| APOE ε4 | 1.77 [1.20–2.60] | 0.004 | 1.60 (0.93–2.75) | 0.090 |
| MCI to Dementia | ||||
| All | Exclude Braak V-VI ( n = 113) | |||
| Variable | HR (95% CI) | Pr(>|z|) | HR (95% CI) | Pr(>|z|) |
| Sex (Male) | 1.04 [0.78–1.38] | 0.80 | 1.12 [0.69–1.83] | 0.67 |
| Age (years) | 0.99 [0.98–1.01] | 0.49 | 0.99 [0.96–1.02] | 0.53 |
| Education (yrs) | 1.03 [0.99–1.09] | 0.12 | 1.03 [0.96–1.1] | 0.39 |
| NFT Braak III-IV | 0.84 [0.50–1.41] | 0.51 | 0.97 [0.56–1.67] | 0.91 |
| NFT Braak V-VI | 1.78 [1.12–2.83] | 0.015 | - | - |
| Limbic LP | 1.02 [0.74–1.42] | 0.82 | 1.30 [0.69–2.46] | 0.41 |
| Neocortical LP | 1.23 [0.92–1.65] | 0.21 | 2.05 [1.15–3.66] | 0.015 |
| APOE ε4 | 1.14 [0.87–1.51] | 0.35 | 1.04 (0.64–1.69) | 0.88 |
HR: Hazard ratio; LP: Lewy pathology; NFT: Neurofibrillary tangles