Table 3.

The clinical manifestations of two critically hospitalized children

Case	Sex	Age (Y)	Duration of Hospitalization	Complaints and Past Medical History	Physical Examination upon Admission	CT scan	Laboratory Results	Treatment	Diagnosis	Outcome
1	Male	11	5 days	Increased bowel movements; Fever for one day; The highest recorded temperature was 39 °C, accompanied by nausea, vomiting, and abdominal pain. Past medical history not reported.	Body temperature of 40.5 °C; pulse rate of 168 beats per minute; Blood pressure of 105/49 mmHg; Respiratory rate of 25 breaths per minute.	Minor inflammation in the lower lobe of the left lung; Head CT revealed brain swelling with decreased density in both cerebral hemispheres and the brainstem.	Troponin T at 963 ng/L (Reference < 100 ng/L); ALT 210.1 U/L, AST 520.9 U/L, CK-MB 129.5 U/L, IL-6 at 8132.61 pg/ml (Reference 0-5.3pg/ml).	Oxygen therapy; Intravenous fluids; Mechanical ventilation.	Flu A-associated acute necrotizing encephalopathy and multi-organ failure	Death
2	Male	4	14 days	4-day history of fever and cough. Received cefotaxime treatment at an outside hospital for 2 days, no significant improvement. Past medical history of cerebral palsy and epilepsy, with a highest recorded temperature of 39 °C.	Body temperature of 38.3℃. Respiratory rate of 20 breaths/min, Height 86 cm, Weight 11.5 kg. Conscious and alert, with average mental state and signs of malnutrition. Tonsils enlarged. Coarse breath sounds in both lungs, symmetrical, with occasional rales. Heart rate 120 beats/min, regular rhythm. Increased muscle tension in all four limbs. Hands are clenched and flexed, lower limbs are stiff.	No CT scan	ALT 810.6 U/L, AST 2249.2 U/L, LDH 3799 U/L, CK 52,436 U/L, CK-MB 510.9 U/L; Respiratory sputum culture: pseudomonas aeruginosa.	Anti-inflammatory treatment	Multiple organ dysfunction syndrome (liver injury, myocarditis); Spastic cerebral palsy; Bronchopneumonia; Flu A.	Condition improved, discharged