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. 1973 Dec;136(4):1121–1124. doi: 10.1042/bj1361121

Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-l-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone) (Short Communication)

Olle Heby *, Sharon Sauter †, Diane H Russell †,‡
PMCID: PMC1166065  PMID: 4786532

Abstract

Administration of methylglyoxal bis(guanylhydrazone) to leukaemic mice results in an early depression followed by a marked elevation of S-adenosyl-l-methionine decarboxylase activity. Further, there is an early prolonged increase in the activity of ornithine decarboxylase, the initial enzyme in the polyamine biosynthetic pathway. Because of the profound effects of methylglyoxal bis(guanylhydrazone) in vivo on the polyamine biosynthetic pathway, the drug can no longer be considered a specific inhibitor of spermidine synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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