Table 1.

The potential DNA repair genes in generating eccDNAs

DNA repair	DNA damage types	Genes	Reference
NHEJ	DSB	KU70/80, XRCC4, LIG4, NHEJ4, POLM	[37, 43, 50, 54]
		APLF	[51–53]
		PRKDC	[37]
MMEJ	DSB	APE2	[37, 60]
HR	DSB	XRCC3, NBS1	[63, 64]
		SHLD2 (FAM35A/B), TP53BP1	[72]
		POLQ, BRCA1, BRCA2, RAD51	[37]
MMR	DNA single-strand break	MSH2, MSH3, MLH1, PMS2	[37, 40]
		BLM	[71]
BER/NER	DNA single-strand break	RAD23B	[73]
		LIG3	[43]
		PARP1, PARP2, FEN1, APE1	[37]