Table 1.
Patient demographics data between patients with and without tranexamic acid
| Total (n = 8042) | TXA (n = 3664) | no TXA (n = 4378) | p-value | ||||
|---|---|---|---|---|---|---|---|
| Age, year (mean ± SD) | 67.9 | ± 10.3 | 67.7 | ± 10.6 | 68.1 | ± 10.0 | 0.241 |
| Male (n, %) | 2236 | (27.8) | 1047 | (28.6) | 1189 | (27.2) | 0.158 |
| BMI, kg/m2 (mean ± SD) | 26.9 | ± 4.3 | 26.9 | ± 4.5 | 26.9 | ± 4.1 | 0.229 |
| Preoperative Hb, g/dL (mean ± SD) | 12.5 | ± 1.7 | 12.2 | ± 1.8 | 12.7 | ± 1.6 | 0.000 |
| Surgical time, min (mean ± SD) | 148 | ± 31 | 142 | ± 30 | 154 | ± 31 | 0.000 |
| Joint (n. %) | < 0.001 | ||||||
| Hip | 1766 | (22.0) | 967 | (26.5) | 796 | (18.2) | |
| Knee | 6276 | (78.0) | 2697 | (73.5) | 3582 | (81.8) | |
| Diagnosis | 0.478 | ||||||
| Osteoarthritis | 6894 | (85.7) | 3086 | (84.3) | 3808 | (87.0) | |
| Osteonecrosis | 699 | (8.7) | 358 | (9.8) | 341 | (7.8) | |
| Rheumatoid arthritis | 195 | (2.4) | 116 | (3.2) | 79 | (1.8) | |
| Ankylosing spondylitis | 24 | (0.3) | 10 | (0.3) | 14 | (0.3) | |
| Posttraumatic osteoarthritis | 153 | (1.9) | 71 | (1.9) | 82 | (1.9) | |
| Hip dysplasia | 70 | (0.9) | 18 | (0.5) | 52 | (1.2) | |
| Gouty arthritis | 5 | (0.1) | 3 | (0.1) | 2 | (0.0) | |
| Lateral (n, %) | 0.834 | ||||||
| Right | 4198 | (52.2) | 1913 | (52.2) | 2285 | (52.2) | |
| Left | 3837 | (47.7) | 1749 | (47.7) | 2088 | (47.7) | |
| Bilateral | 6 | (0.1) | 2 | (0.1) | 4 | (0.1) | |
| CCI > 2 (n, %) | 5222 | (64.9) | 2258 | (61.7) | 2964 | (67.7) | < 0.001 |
| Comorbidities (n, %) | |||||||
| Heart disease | 368 | (4.6) | 165 | (4.5) | 203 | (4.6) | 0.775 |
| COPD | 192 | (2.4) | 100 | (2.7) | 92 | (2.1) | 0.066 |
| Diabetes | 1738 | (21.6) | 760 | (20.7) | 978 | (22.3) | 0.083 |
| Renal failure | 1629 | (20.3) | 430 | (11.8) | 1199 | (27.4) | < 0.001 |
| Liver disease | 164 | (2.0) | 57 | (1.6) | 107 | (2.4) | 0.005 |
| Rheumatoid Arthritis | 266 | (3.3) | 97 | (2.6) | 169 | (3.9) | 0.002 |
| ASA (n, %) | < 0.001a | ||||||
| 1 | 146 | (1.8) | 42 | (1.1) | 105 | (2.4) | |
| 2 | 4810 | (59.8) | 2146 | (58.6) | 2664 | (60.8) | |
| 3 | 3085 | (38.4) | 1476 | (40.3) | 1609 | (36.8) | |
| 4 | 1 | (0) | 1 | (0) | 0 | (0) | |
| Anesthesia (n, %) | < 0.001a | ||||||
| General | 7253 | (90.2) | 3227 | (88.1) | 4026 | (92.0) | |
| Regional | 789 | (9.8) | 437 | (11.9) | 352 | (8.0) | |
a fisher’s exact test
TXA, tranexamic acid; BMI, body mass index; Hb, hemoglobin; TKA, total knee arthroplasty; CCI, Charlson Comorbidity Index; ASA, American Society of Anesthesiology; COPD, chronic obstructive pulmonary disease; IQR, interquartile range