Table 3.
Univariate and multivariate analysis for periprosthetic joint infection
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95%CI | p-value | Adjust OR | 95%CI | p-value | |
| TXA | 0.49 | 0.34–0.71 | < 0.001 | 0.54 | 0.36–0.80 | 0.002 |
| Age (per 1-year increment) | 1.00 | 0.99–1.02 | 0.644 | 1.00 | 0.98–1.02 | 0.680 |
| Male | 1.34 | 0.93–1.92 | 0.119 | 1.53 | 1.03–2.28 | 0.039 |
| Surgery: TKA | 2.08 | 1.23–3.51 | 0.006 | 2.23 | 1.24-4.00 | 0.008 |
| BMI (per 1-kg/m2 increment) | 1.03 | 0.99–1.07 | 0.108 | 1.02 | 0.98–1.07 | 0.289 |
| Laterality: Right | 0.84 | 0.60–1.19 | 0.335 | 0.84 | 0.59–1.19 | 0.304 |
| Preoperative Hb (per 1- g/dL increment) | 1.05 | 0.95–1.15 | 0.390 | 0.97 | 0.87–1.08 | 0.601 |
| Surgical time (per 1- min increment) | 1.01 | 1.00-1.01 | 0.011 | 1.00 | 0.99–1.01 | 0.153 |
| CCI > 2 | 1.17 | 0.81–1.70 | 0.396 | - | - | -^ |
| Heart disease | 0.81 | 0.33-2.00 | 0.650 | 0.73 | 0.29–1.82 | 0.499 |
| COPD | 1.27 | 0.47–3.48 | 0.637 | 1.23 | 0.44–3.42 | 0.695 |
| Diabetes | 1.10 | 0.74–1.66 | 0.632 | 0.95 | 0.62–1.45 | 0.809 |
| Renal failure | 1.25 | 0.84–1.87 | 0.272 | 1.07 | 0.71–1.62 | 0.742 |
| Liver disease | 1.90 | 0.77–4.72 | 0.164 | 1.79 | 0.71–4.47 | 0.215 |
| Rheumatoid Arthritis | 1.39 | 0.61–3.18 | 0.436 | 1.47 | 0.62–3.50 | 0.377 |
| ASA > 3 | 0.75 | 0.53–1.06 | 0.108 | 0.73 | 0.51–1.07 | 0.104 |
| General anesthesia | 0.66 | 0.34–1.31 | 0.237 | 0.62 | 0.31–1.25 | 0.184 |
^CCI > 2 is not involved into analysis due to collinearity with following comorbidities
TXA, tranexamic acid; TKA, total knee arthroplasty; BMI, body mass index; Hb, hemoglobin; CCI, Charlson Comorbidity Index; COPD, chronic obstructive pulmonary disease; ASA, American Society of Anesthesiology; OR, odds ratio; CI, confidence interval