Table 1.
Rank | First Author | Year | Title | Reference | Journal | WoS Citations | WoS Citations per Year (Since Publication) | Dimensions Citations | AAS | AAS per Year (Since Publication) |
---|---|---|---|---|---|---|---|---|---|---|
1 | Sakai D | 2003 | Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration | [31] | Biomaterials | 372 | 17.71 | 339 | 9 | 0.43 |
2 | Sakai D | 2006 | Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc | [32] | Biomaterials | 325 | 18.06 | 307 | 6 | 0.33 |
3 | Orozco L | 2011 | Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study | [33] | Transplantation | 324 | 24.92 | 343 | 32 | 2.46 |
4 | Sakai D | 2005 | Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration | [34] | Spine | 316 | 16.63 | 295 | 19 | 1.00 |
5 | Sakai D | 2012 | Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc | [35] | Nature Communications | 282 | 23.50 | 295 | 8 | 0.67 |
6 | Richardson SM | 2016 | Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration | [36] | Methods | 270 | 33.75 | 315 | 7 | 0.88 |
7 | Crevensten G | 2004 | Intervertebral disc cell therapy for regeneration: Mesenchymal stem cell implantation in rat intervertebral discs | [37] | Annals of Biomedical Engineering | 267 | 13.35 | 268 | 6 | 0.30 |
8 | Hiyama A | 2008 | Transplantation of mesenchymal stem cells in a canine disc degeneration model | [38] | Journal of Orthopaedic Research | 207 | 12.94 | 204 | 9 | 0.56 |
9 | Vadalà G | 2012 | Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation | [39] | Journal of Tissue Engineering and Regenerative Medicine | 201 | 16.75 | 214 | 10 | 0.83 |
10 | Yoshikawa T | 2010 | Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies | [40] | Spine | 184 | 13.14 | 190 | 0 | 0.00 |
11 | Sobajima S | 2008 | Feasibility of a stem cell therapy for intervertebral disc degeneration | [41] | Spine Journal | 172 | 10.75 | 166 | 5 | 0.31 |
12 | Henriksson HB | 2009 | Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model | [42] | Spine | 161 | 10.73 | 164 | 6 | 0.40 |
13 | Ganey T | 2009 | Intervertebral disc repair using adipose tissue-derived stem and regenerative cells experiments in a canine model | [43] | Spine | 150 | 10.00 | 150 | 5 | 0.33 |
14 | Leung VY | 2006 | Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction | [44] | European Spine Journal | 148 | 8.22 | 148 | 3 | 0.17 |
15 | Zhang YG | 2005 | Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans | [45] | Clinical Orthopaedics and Related Research | 134 | 7.05 | 138 | 3 | 0.16 |
16 | Sakai D | 2008 | Future perspectives of cell-based therapy for intervertebral disc disease | [46] | European Spine Journal | 134 | 8.38 | 129 | 0 | 0.00 |
17 | Serigano K | 2010 | Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model | [47] | Journal of Orthopaedic Research | 133 | 9.50 | 132 | 0 | 0.00 |
18 | Noriega DC | 2017 | Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: a randomized controlled trial | [48] | Transplantation | 122 | 17.43 | 127 | 20 | 2.86 |
19 | Yang Fan | 2009 | Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells | [49] | Molecular Therapy | 118 | 7.87 | 120 | 3 | 0.20 |
20 | Miyamoto T | 2010 | Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits | [50] | Arthritis Research & Therapy | 105 | 7.50 | 108 | 3 | 0.21 |
21 | Pettine K | 2015 | Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months | [51] | Stem Cells | 102 | 11.33 | 120 | 6 | 0.67 |
22 | Acosta FL Jr | 2011 | Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells | [52] | Tissue Engineering Part A | 101 | 7.77 | 115 | 4 | 0.31 |
23 | Kumar H | 2017 | Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study | [53] | Stem Cell Research & Therapy | 95 | 13.57 | 95 | 2 | 0.29 |
24 | Yang H | 2010 | Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-beta 1 decrease rabbit intervertebral disc degeneration | [54] | Spine Journal | 85 | 6.07 | 78 | 6 | 0.43 |
25 | Jeong JH | 2010 | Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells | [55] | Acta Neurochirurgica | 83 | 5.93 | 74 | 0 | 0.00 |
26 | Hoogendoorn RJ | 2008 | Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future | [56] | Journal of Cellular and Molecular Medicine | 74 | 4.63 | 75 | 3 | 0.19 |
27 | Feng G | 2011 | Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration Laboratory investigation | [57] | Journal of Neurosurgery: Spine | 74 | 5.69 | 76 | 0 | 0.00 |
28 | Yim RL | 2014 | A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics | [58] | Stem Cells and Development | 74 | 7.40 | 74 | 6 | 0.60 |
29 | Sakai D | 2017 | Cell therapy for intervertebral disc repair: Clinical perspective | [59] | Journal of Orthopaedic Translation | 72 | 10.29 | 80 | 6 | 0.86 |
30 | Clouet J | 2019 | Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies | [60] | Advanced Drug Delivery Reviews | 71 | 14.20 | 93 | 2 | 0.40 |
31 | Leung VY | 2014 | Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair | [61] | Stem Cells | 71 | 7.10 | 76 | 8 | 0.80 |
32 | Haufe SM | 2006 | Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs | [62] | Stem Cells and Development | 70 | 3.89 | 77 | 3 | 0.17 |
33 | Ho G | 2008 | Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration | [63] | Connective Tissue Research | 69 | 4.31 | 64 | 3 | 0.19 |
34 | Wei A | 2009 | The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs | [64] | Journal of Orthopaedic Research | 66 | 4.40 | 65 | 0 | 0.00 |
35 | Vadalà G | 2016 | Stem cells sources for intervertebral disc regeneration | [65] | World Journal of Stem Cells | 65 | 8.13 | 65 | 2 | 0.25 |
36 | Zeng Y | 2015 | Injectable microcryogels reinforced alginate encapsulation of mesenchymal stromal cells for leak-proof delivery and alleviation of canine disc degeneration | [66] | Biomaterials | 65 | 7.22 | 70 | 0 | 0.00 |
37 | Elabd C | 2016 | Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study | [67] | Journal of Translational Medicine | 64 | 8.00 | 73 | 535 | 66.88 |
38 | Pettine K | 2017 | Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up | [68] | International Orthopaedics | 62 | 8.86 | 66 | 7 | 1.00 |
39 | Yang H | 2015 | TGF-β l suppresses inflammation in cell therapy for intervertebral disc degeneration | [69] | Scientific Reports | 59 | 6.56 | 46 | 1 | 0.11 |
40 | Centeno C | 2017 | Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy | [70] | Journal of Translational Medicine | 58 | 8.29 | 66 | 93 | 13.29 |
41 | Wang H | 2014 | Utilization of stem cells in alginate for nucleus pulposus tissue engineering | [71] | Tissue Engineering Part A | 58 | 5.80 | 56 | 1 | 0.10 |
42 | Chun HJ | 2012 | Tansplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs | [72] | World Neurosurgery | 58 | 4.83 | 51 | 1 | 0.08 |
43 | Liang CZ | 2013 | Dual release of dexamethasone and TGF-β3 from polymeric microspheres for stem cell matrix accumulation in a rat disc degeneration model | [73] | Acta Biomaterialia | 56 | 5.09 | 56 | 3 | 0.27 |
44 | Murrell W | 2009 | Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model | [74] | Spine Journal | 56 | 3.73 | 53 | 0 | 0.00 |
45 | Allon AA | 2010 | Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model | [75] | Spine Journal | 54 | 3.86 | 61 | 0 | 0.00 |
46 | Pettine K | 2016 | Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up | [76] | International Orthopaedics | 53 | 6.63 | 68 | 37 | 4.63 |
47 | Zhou X | 2018 | Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus | [77] | Acta Biomaterialia | 52 | 8.67 | 60 | 1 | 0.17 |
48 | Comella K | 2017 | Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease | [78] | Journal of Translational Medicine | 52 | 7.43 | 66 | 97 | 13.86 |
49 | Jeong JH | 2009 | Human mesenchymal stem cells implantation into the degenerated coccygeal disc of the rat | [79] | Cytotechnology | 49 | 3.27 | 45 | 0 | 0.00 |
50 | Sakai D | 2015 | Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study | [80] | Spine Journal | 49 | 5.44 | 50 | 1 | 0.11 |
51 | Pang X | 2014 | Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain | [81] | Pain Physician | 48 | 4.80 | 51 | 0 | 0.00 |
52 | Binch ALA | 2021 | Cell-based strategies for IVD repair: clinical progress and translational obstacles | [82] | Nature Reviews Rheumatology | 46 | 15.33 | 55 | 26 | 8.67 |
53 | Loibl M | 2019 | Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells? | [83] | JOR Spine | 45 | 9.00 | 49 | 0 | 0.00 |
54 | Oehme D | 2014 | Mesenchymal progenitor cells combined with pentosan polysulfate mediating disc regeneration at the time of microdiscectomy: a preliminary study in an ovine model | [84] | Journal of Neurosurgery: Spine | 45 | 4.50 | 54 | 4 | 0.40 |
55 | Bendtsen M | 2011 | Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration | [85] | Spine | 44 | 4.89 | 46 | 0 | 0.00 |
56 | Wang Z | 2015 | Efficacy of intervertebral disc regeneration with stem cells: a systematic review and meta-analysis of animal controlled trials | [86] | Gene | 44 | 3.38 | 50 | 23 | 2.56 |
57 | Marfia G | 2014 | Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration | [87] | Arthritis Research & Therapy | 43 | 4.30 | 43 | 6 | 0.60 |
58 | Hee HT | 2010 | Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc | [88] | Journal of Bone and Joint Surgery: British Volume | 42 | 3.00 | 43 | 0 | 0.00 |
59 | Anderson DG | 2005 | Cell-based therapy for disc repair | [89] | Spine Journal | 41 | 2.16 | 47 | 0 | 0.00 |
60 | Schol J | 2019 | Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials | [90] | International Orthopaedics | 39 | 7.80 | 49 | 3 | 0.60 |
61 | Omlor GW | 2010 | Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs | [91] | European Spine Journal | 39 | 2.79 | 41 | 0 | 0.00 |
62 | Zeckser J | 2016 | Multipotent mesenchymal stem cell treatment for discogenic low back pain and disc degeneration | [92] | Stem Cells International | 37 | 4.63 | 38 | 5 | 0.63 |
63 | Cai F | 2015 | Evaluation of intervertebral disc regeneration with implantation of bone marrow mesenchymal stem cells (BMSCs) using quantitative T2 mapping: a study in rabbits | [93] | International Orthopaedics | 36 | 4.00 | 35 | 0 | 0.00 |
64 | Sheyn D | 2019 | Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model | [94] | Theranostics | 34 | 6.80 | 42 | 6 | 1.20 |
65 | Wang YT | 2010 | Regeneration potential and mechanism of bone marrow mesenchymal stem cell transplantation for treating intervertebral disc degeneration | [95] | Journal of Orthopaedic Science | 33 | 2.36 | 25 | 0 | 0.00 |
66 | Sun W | 2014 | Sox9 gene transfer enhanced regenerative effect of bone marrow mesenchymal stem cells on the degenerated intervertebral disc in a rabbit model | [96] | PLoS One | 31 | 3.10 | 26 | 0 | 0.00 |
67 | Chen X | 2016 | A comparison between nucleus pulposus-derived stem cell transplantation and nucleus pulposus cell transplantation for the treatment of intervertebral disc degeneration in a rabbit model | [97] | International Journal of Surgery | 30 | 3.75 | 29 | 0 | 0.00 |
68 | Gou S | 2014 | Stem cell therapy for intervertebral disk regeneration | [98] | American Journal of Physical Medicine & Rehabilitation | 30 | 3.00 | 33 | 3 | 0.30 |
69 | Tam V | 2014 | A comparison of intravenous and intradiscal delivery of multipotential stem cells on the healing of injured intervertebral disk | [99] | Journal of Orthopaedic Research | 30 | 3.00 | 34 | 6 | 0.60 |
70 | Zhou X | 2018 | Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration | [100] | Acta Biomaterialia | 30 | 5.00 | 37 | 0 | 0.00 |
71 | Hussain I | 2019 | Mesenchymal stem cell-seeded high-density collagen gel for annular repair: 6-week results from in vivo sheep models | [101] | Neurosurgery | 29 | 5.80 | 31 | 2 | 0.40 |
72 | Freeman BJC | 2016 | Allogeneic mesenchymal precursor cells promote healing in postero-lateral annular lesions and improve indices of lumbar intervertebral disc degeneration in an ovine model | [102] | Spine | 28 | 3.50 | 34 | 3 | 0.38 |
73 | Ahn J | 2015 | Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration | [103] | Stem Cell Research & Therapy | 28 | 3.11 | 32 | 4 | 0.44 |
74 | Shu CC | 2017 | A histopathological scheme for the quantitative scoring of intervertebral disc degeneration and the therapeutic utility of adult mesenchymal stem cells for intervertebral disc regeneration | [104] | International Journal of Molecular Sciences | 27 | 3.86 | 31 | 4 | 0.57 |
75 | Melrose J | 2016 | Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds | [105] | Regenerative Medicine | 26 | 3.25 | 26 | 1 | 0.13 |
76 | Migliorini F | 2019 | Autogenic mesenchymal stem cells for intervertebral disc regeneration | [106] | International Orthopaedics | 26 | 5.20 | 31 | 2 | 0.40 |
77 | Ishiguro H | 2019 | Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model | [107] | Acta Biomaterialia | 25 | 5.00 | 30 | 0 | 0.00 |
78 | Li YY | 2014 | Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc: reduced risk of osteophyte formation | [108] | Tissue Engineering Part A | 25 | 2.50 | 35 | 1 | 0.10 |
79 | Wang F | 2019 | Injectable hydrogel combined with nucleus pulposus-derived mesenchymal stem cells for the treatment of degenerative intervertebral disc in rats | [109] | Stem Cells International | 25 | 5.00 | 32 | 0 | 0.00 |
80 | Xu J | 2016 | BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration | [110] | FEBS Journal | 22 | 2.75 | 24 | 4 | 0.50 |
81 | Hiraishi S | 2018 | Discogenic cell transplantation directly from a cryopreserved state in an induced intervertebral disc degeneration canine model | [111] | JOR Spine | 21 | 3.50 | 21 | 57 | 9.50 |
82 | Wang W | 2018 | Transplantation of hypoxic-Preconditioned bone mesenchymal stem cells retards intervertebral disc degeneration via enhancing implanted cell survival and migration in rats | [112] | Stem Cells International | 21 | 3.50 | 30 | 0 | 0.00 |
83 | Silverman LI | 2020 | In vitro and in vivo evaluation of discogenic cells, an investigational cell therapy for disc degeneration | [113] | Spine Journal | 19 | 4.75 | 18 | 52 | 13.00 |
84 | Liao JC | 2016 | Cell therapy using bone marrow-derived stem cell overexpressing BMP-7 for degenerative discs in a rat tail disc model | [114] | International Journal of Molecular Sciences | 19 | 2.38 | 20 | 1 | 0.13 |
85 | James G | 2016 | Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber | [115] | Spine | 19 | 2.38 | 21 | 2 | 0.25 |
86 | Maidhof R | 2017 | Timing of mesenchymal stem cell delivery impacts the fate and therapeutic potential in intervertebral disc repair | [116] | Journal of Orthopaedic Research | 19 | 2.71 | 21 | 1 | 0.14 |
87 | Steffen F | 2017 | Bone marrow-derived mesenchymal stem cells as autologous therapy in dogs with naturally occurring intervertebral disc disease: feasibility, safety, and preliminary results | [117] | Tissue Engineering Part C: Methods | 18 | 2.57 | 20 | 70 | 10.00 |
88 | Wang SZ | 2016 | Intervertebral disc regeneration using platelet-rich plasma-containing bone marrow-derived mesenchymal stem cells: A preliminary investigation | [118] | Molecular Medicine Reports | 18 | 2.25 | 16 | 1 | 0.13 |
89 | Wei JN | 2016 | Transplantation of CXCR4 overexpressed mesenchymal stem cells augments regeneration in degenerated intervertebral discs | [119] | DNA and Cell Biology | 18 | 2.25 | 22 | 6 | 0.75 |
90 | Henriksson HB | 2019 | The traceability of mesenchymal stromal cells after injection into degenerated discs in patients with low back pain | [120] | Stem Cells and Development | 17 | 3.40 | 19 | 3 | 0.60 |
91 | Beeravolu N | 2018 | Human umbilical cord derivatives regenerate intervertebral disc | [121] | Journal of Tissue Engineering and Regenerative Medicine | 16 | 2.67 | 20 | 13 | 2.17 |
92 | Chiang ER | 2019 | Use of allogeneic hypoxic mesenchymal stem cells for treating disc degeneration in rabbits | [122] | Journal of Orthopaedic Research | 16 | 3.20 | 18 | 2 | 0.40 |
93 | Croft AS | 2021 | The application of mesenchymal stromal cells and their homing capabilities to regenerate the intervertebral disc | [123] | International Journal of Molecular Sciences | 16 | 5.33 | 19 | 2 | 0.67 |
94 | Sun Y | 2019 | Clinical trials of intervertebral disc regeneration: current status and future developments | [124] | International Orthopaedics | 15 | 3.00 | 20 | 1 | 0.20 |
95 | Hang D | 2017 | One-stage positron emission tomography and magnetic resonance imaging to assess mesenchymal stem cell survival in a canine model of intervertebral disc degeneration | [125] | Stem Cells and Development | 15 | 2.14 | 18 | 0 | 0.00 |
96 | Hou Y | 2016 | Study design: in vitro and in vivo assessment of bone morphogenic protein 2 combined with platelet-rich plasma on treatment of disc degeneration | [126] | International Orthopaedics | 15 | 1.88 | 14 | 0 | 0.00 |
97 | Daly CD | 2018 | Mesenchymal progenitor cells primed with pentosan polysulfate promote lumbar intervertebral disc regeneration in an ovine model of microdiscectomy | [127] | Spine Journal | 14 | 2.33 | 21 | 3 | 0.50 |
98 | Feng G | 2020 | Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification | [128] | Biomaterials | 14 | 3.50 | 18 | 1 | 0.25 |
99 | Zhou Y | 2014 | Effects of transplantation of hTIMP-1-expressing bone marrow mesenchymal stem cells on the extracellular matrix of degenerative intervertebral discs in an in vivo rabbit model | [129] | Spine | 14 | 1.40 | 20 | 1 | 0.10 |
100 | Shu CC | 2018 | Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration | [130] | JOR Spine | 13 | 2.17 | 17 | 0 | 0.00 |
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