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. 2024 Dec 19;25:1029. doi: 10.1186/s12891-024-08131-4

Table 1.

The top 100 works on SCT in IDD according to the number of WoS citations

Rank First Author Year Title Reference Journal WoS Citations WoS Citations per Year (Since Publication) Dimensions Citations AAS AAS per Year (Since Publication)
1 Sakai D 2003 Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration [31] Biomaterials 372 17.71 339 9 0.43
2 Sakai D 2006 Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc [32] Biomaterials 325 18.06 307 6 0.33
3 Orozco L 2011 Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study [33] Transplantation 324 24.92 343 32 2.46
4 Sakai D 2005 Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration [34] Spine 316 16.63 295 19 1.00
5 Sakai D 2012 Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc [35] Nature Communications 282 23.50 295 8 0.67
6 Richardson SM 2016 Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration [36] Methods 270 33.75 315 7 0.88
7 Crevensten G 2004 Intervertebral disc cell therapy for regeneration: Mesenchymal stem cell implantation in rat intervertebral discs [37] Annals of Biomedical Engineering 267 13.35 268 6 0.30
8 Hiyama A 2008 Transplantation of mesenchymal stem cells in a canine disc degeneration model [38] Journal of Orthopaedic Research 207 12.94 204 9 0.56
9 Vadalà G 2012 Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation [39] Journal of Tissue Engineering and Regenerative Medicine 201 16.75 214 10 0.83
10 Yoshikawa T 2010 Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies [40] Spine 184 13.14 190 0 0.00
11 Sobajima S 2008 Feasibility of a stem cell therapy for intervertebral disc degeneration [41] Spine Journal 172 10.75 166 5 0.31
12 Henriksson HB 2009 Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model [42] Spine 161 10.73 164 6 0.40
13 Ganey T 2009 Intervertebral disc repair using adipose tissue-derived stem and regenerative cells experiments in a canine model [43] Spine 150 10.00 150 5 0.33
14 Leung VY 2006 Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction [44] European Spine Journal 148 8.22 148 3 0.17
15 Zhang YG 2005 Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans [45] Clinical Orthopaedics and Related Research 134 7.05 138 3 0.16
16 Sakai D 2008 Future perspectives of cell-based therapy for intervertebral disc disease [46] European Spine Journal 134 8.38 129 0 0.00
17 Serigano K 2010 Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model [47] Journal of Orthopaedic Research 133 9.50 132 0 0.00
18 Noriega DC 2017 Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: a randomized controlled trial [48] Transplantation 122 17.43 127 20 2.86
19 Yang Fan 2009 Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells [49] Molecular Therapy 118 7.87 120 3 0.20
20 Miyamoto T 2010 Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits [50] Arthritis Research & Therapy 105 7.50 108 3 0.21
21 Pettine K 2015 Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months [51] Stem Cells 102 11.33 120 6 0.67
22 Acosta FL Jr 2011 Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells [52] Tissue Engineering Part A 101 7.77 115 4 0.31
23 Kumar H 2017 Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study [53] Stem Cell Research & Therapy 95 13.57 95 2 0.29
24 Yang H 2010 Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-beta 1 decrease rabbit intervertebral disc degeneration [54] Spine Journal 85 6.07 78 6 0.43
25 Jeong JH 2010 Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells [55] Acta Neurochirurgica 83 5.93 74 0 0.00
26 Hoogendoorn RJ 2008 Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future [56] Journal of Cellular and Molecular Medicine 74 4.63 75 3 0.19
27 Feng G 2011 Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration Laboratory investigation [57] Journal of Neurosurgery: Spine 74 5.69 76 0 0.00
28 Yim RL 2014 A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics [58] Stem Cells and Development 74 7.40 74 6 0.60
29 Sakai D 2017 Cell therapy for intervertebral disc repair: Clinical perspective [59] Journal of Orthopaedic Translation 72 10.29 80 6 0.86
30 Clouet J 2019 Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies [60] Advanced Drug Delivery Reviews 71 14.20 93 2 0.40
31 Leung VY 2014 Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair [61] Stem Cells 71 7.10 76 8 0.80
32 Haufe SM 2006 Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs [62] Stem Cells and Development 70 3.89 77 3 0.17
33 Ho G 2008 Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration [63] Connective Tissue Research 69 4.31 64 3 0.19
34 Wei A 2009 The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs [64] Journal of Orthopaedic Research 66 4.40 65 0 0.00
35 Vadalà G 2016 Stem cells sources for intervertebral disc regeneration [65] World Journal of Stem Cells 65 8.13 65 2 0.25
36 Zeng Y 2015 Injectable microcryogels reinforced alginate encapsulation of mesenchymal stromal cells for leak-proof delivery and alleviation of canine disc degeneration [66] Biomaterials 65 7.22 70 0 0.00
37 Elabd C 2016 Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study [67] Journal of Translational Medicine 64 8.00 73 535 66.88
38 Pettine K 2017 Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up [68] International Orthopaedics 62 8.86 66 7 1.00
39 Yang H 2015 TGF-β l suppresses inflammation in cell therapy for intervertebral disc degeneration [69] Scientific Reports 59 6.56 46 1 0.11
40 Centeno C 2017 Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy [70] Journal of Translational Medicine 58 8.29 66 93 13.29
41 Wang H 2014 Utilization of stem cells in alginate for nucleus pulposus tissue engineering [71] Tissue Engineering Part A 58 5.80 56 1 0.10
42 Chun HJ 2012 Tansplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs [72] World Neurosurgery 58 4.83 51 1 0.08
43 Liang CZ 2013 Dual release of dexamethasone and TGF-β3 from polymeric microspheres for stem cell matrix accumulation in a rat disc degeneration model [73] Acta Biomaterialia 56 5.09 56 3 0.27
44 Murrell W 2009 Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model [74] Spine Journal 56 3.73 53 0 0.00
45 Allon AA 2010 Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model [75] Spine Journal 54 3.86 61 0 0.00
46 Pettine K 2016 Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up [76] International Orthopaedics 53 6.63 68 37 4.63
47 Zhou X 2018 Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus [77] Acta Biomaterialia 52 8.67 60 1 0.17
48 Comella K 2017 Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease [78] Journal of Translational Medicine 52 7.43 66 97 13.86
49 Jeong JH 2009 Human mesenchymal stem cells implantation into the degenerated coccygeal disc of the rat [79] Cytotechnology 49 3.27 45 0 0.00
50 Sakai D 2015 Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study [80] Spine Journal 49 5.44 50 1 0.11
51 Pang X 2014 Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain [81] Pain Physician 48 4.80 51 0 0.00
52 Binch ALA 2021 Cell-based strategies for IVD repair: clinical progress and translational obstacles [82] Nature Reviews Rheumatology 46 15.33 55 26 8.67
53 Loibl M 2019 Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells? [83] JOR Spine 45 9.00 49 0 0.00
54 Oehme D 2014 Mesenchymal progenitor cells combined with pentosan polysulfate mediating disc regeneration at the time of microdiscectomy: a preliminary study in an ovine model [84] Journal of Neurosurgery: Spine 45 4.50 54 4 0.40
55 Bendtsen M 2011 Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration [85] Spine 44 4.89 46 0 0.00
56 Wang Z 2015 Efficacy of intervertebral disc regeneration with stem cells: a systematic review and meta-analysis of animal controlled trials [86] Gene 44 3.38 50 23 2.56
57 Marfia G 2014 Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration [87] Arthritis Research & Therapy 43 4.30 43 6 0.60
58 Hee HT 2010 Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc [88] Journal of Bone and Joint Surgery: British Volume 42 3.00 43 0 0.00
59 Anderson DG 2005 Cell-based therapy for disc repair [89] Spine Journal 41 2.16 47 0 0.00
60 Schol J 2019 Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials [90] International Orthopaedics 39 7.80 49 3 0.60
61 Omlor GW 2010 Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs [91] European Spine Journal 39 2.79 41 0 0.00
62 Zeckser J 2016 Multipotent mesenchymal stem cell treatment for discogenic low back pain and disc degeneration [92] Stem Cells International 37 4.63 38 5 0.63
63 Cai F 2015 Evaluation of intervertebral disc regeneration with implantation of bone marrow mesenchymal stem cells (BMSCs) using quantitative T2 mapping: a study in rabbits [93] International Orthopaedics 36 4.00 35 0 0.00
64 Sheyn D 2019 Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model [94] Theranostics 34 6.80 42 6 1.20
65 Wang YT 2010 Regeneration potential and mechanism of bone marrow mesenchymal stem cell transplantation for treating intervertebral disc degeneration [95] Journal of Orthopaedic Science 33 2.36 25 0 0.00
66 Sun W 2014 Sox9 gene transfer enhanced regenerative effect of bone marrow mesenchymal stem cells on the degenerated intervertebral disc in a rabbit model [96] PLoS One 31 3.10 26 0 0.00
67 Chen X 2016 A comparison between nucleus pulposus-derived stem cell transplantation and nucleus pulposus cell transplantation for the treatment of intervertebral disc degeneration in a rabbit model [97] International Journal of Surgery 30 3.75 29 0 0.00
68 Gou S 2014 Stem cell therapy for intervertebral disk regeneration [98] American Journal of Physical Medicine & Rehabilitation 30 3.00 33 3 0.30
69 Tam V 2014 A comparison of intravenous and intradiscal delivery of multipotential stem cells on the healing of injured intervertebral disk [99] Journal of Orthopaedic Research 30 3.00 34 6 0.60
70 Zhou X 2018 Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration [100] Acta Biomaterialia 30 5.00 37 0 0.00
71 Hussain I 2019 Mesenchymal stem cell-seeded high-density collagen gel for annular repair: 6-week results from in vivo sheep models [101] Neurosurgery 29 5.80 31 2 0.40
72 Freeman BJC 2016 Allogeneic mesenchymal precursor cells promote healing in postero-lateral annular lesions and improve indices of lumbar intervertebral disc degeneration in an ovine model [102] Spine 28 3.50 34 3 0.38
73 Ahn J 2015 Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration [103] Stem Cell Research & Therapy 28 3.11 32 4 0.44
74 Shu CC 2017 A histopathological scheme for the quantitative scoring of intervertebral disc degeneration and the therapeutic utility of adult mesenchymal stem cells for intervertebral disc regeneration [104] International Journal of Molecular Sciences 27 3.86 31 4 0.57
75 Melrose J 2016 Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds [105] Regenerative Medicine 26 3.25 26 1 0.13
76 Migliorini F 2019 Autogenic mesenchymal stem cells for intervertebral disc regeneration [106] International Orthopaedics 26 5.20 31 2 0.40
77 Ishiguro H 2019 Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model [107] Acta Biomaterialia 25 5.00 30 0 0.00
78 Li YY 2014 Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc: reduced risk of osteophyte formation [108] Tissue Engineering Part A 25 2.50 35 1 0.10
79 Wang F 2019 Injectable hydrogel combined with nucleus pulposus-derived mesenchymal stem cells for the treatment of degenerative intervertebral disc in rats [109] Stem Cells International 25 5.00 32 0 0.00
80 Xu J 2016 BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration [110] FEBS Journal 22 2.75 24 4 0.50
81 Hiraishi S 2018 Discogenic cell transplantation directly from a cryopreserved state in an induced intervertebral disc degeneration canine model [111] JOR Spine 21 3.50 21 57 9.50
82 Wang W 2018 Transplantation of hypoxic-Preconditioned bone mesenchymal stem cells retards intervertebral disc degeneration via enhancing implanted cell survival and migration in rats [112] Stem Cells International 21 3.50 30 0 0.00
83 Silverman LI 2020 In vitro and in vivo evaluation of discogenic cells, an investigational cell therapy for disc degeneration [113] Spine Journal 19 4.75 18 52 13.00
84 Liao JC 2016 Cell therapy using bone marrow-derived stem cell overexpressing BMP-7 for degenerative discs in a rat tail disc model [114] International Journal of Molecular Sciences 19 2.38 20 1 0.13
85 James G 2016 Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber [115] Spine 19 2.38 21 2 0.25
86 Maidhof R 2017 Timing of mesenchymal stem cell delivery impacts the fate and therapeutic potential in intervertebral disc repair [116] Journal of Orthopaedic Research 19 2.71 21 1 0.14
87 Steffen F 2017 Bone marrow-derived mesenchymal stem cells as autologous therapy in dogs with naturally occurring intervertebral disc disease: feasibility, safety, and preliminary results [117] Tissue Engineering Part C: Methods 18 2.57 20 70 10.00
88 Wang SZ 2016 Intervertebral disc regeneration using platelet-rich plasma-containing bone marrow-derived mesenchymal stem cells: A preliminary investigation [118] Molecular Medicine Reports 18 2.25 16 1 0.13
89 Wei JN 2016 Transplantation of CXCR4 overexpressed mesenchymal stem cells augments regeneration in degenerated intervertebral discs [119] DNA and Cell Biology 18 2.25 22 6 0.75
90 Henriksson HB 2019 The traceability of mesenchymal stromal cells after injection into degenerated discs in patients with low back pain [120] Stem Cells and Development 17 3.40 19 3 0.60
91 Beeravolu N 2018 Human umbilical cord derivatives regenerate intervertebral disc [121] Journal of Tissue Engineering and Regenerative Medicine 16 2.67 20 13 2.17
92 Chiang ER 2019 Use of allogeneic hypoxic mesenchymal stem cells for treating disc degeneration in rabbits [122] Journal of Orthopaedic Research 16 3.20 18 2 0.40
93 Croft AS 2021 The application of mesenchymal stromal cells and their homing capabilities to regenerate the intervertebral disc [123] International Journal of Molecular Sciences 16 5.33 19 2 0.67
94 Sun Y 2019 Clinical trials of intervertebral disc regeneration: current status and future developments [124] International Orthopaedics 15 3.00 20 1 0.20
95 Hang D 2017 One-stage positron emission tomography and magnetic resonance imaging to assess mesenchymal stem cell survival in a canine model of intervertebral disc degeneration [125] Stem Cells and Development 15 2.14 18 0 0.00
96 Hou Y 2016 Study design: in vitro and in vivo assessment of bone morphogenic protein 2 combined with platelet-rich plasma on treatment of disc degeneration [126] International Orthopaedics 15 1.88 14 0 0.00
97 Daly CD 2018 Mesenchymal progenitor cells primed with pentosan polysulfate promote lumbar intervertebral disc regeneration in an ovine model of microdiscectomy [127] Spine Journal 14 2.33 21 3 0.50
98 Feng G 2020 Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification [128] Biomaterials 14 3.50 18 1 0.25
99 Zhou Y 2014 Effects of transplantation of hTIMP-1-expressing bone marrow mesenchymal stem cells on the extracellular matrix of degenerative intervertebral discs in an in vivo rabbit model [129] Spine 14 1.40 20 1 0.10
100 Shu CC 2018 Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration [130] JOR Spine 13 2.17 17 0 0.00

WoS Web of Science, AAS Altmetric Attention Score