Table 2. Correlation between pretreatment clinical characteristics and clinical response (ORR, DCR) in 88 patients with advanced gastric cancer.
| Responses group | Non-ORR N (%) | ORR N (%) | χ2 (ORR) | P value (ORR) | Non-DCR N (%) | DCR N (%) | χ2 (DCR) | P value (DCR) |
|---|---|---|---|---|---|---|---|---|
| Age (years) | 0.259 | 0.611 | 0.812 | 0.367 | ||||
| <60 | 9 (20.5) | 35 (79.5) | 8 (18.2) | 36 (81.8) | ||||
| ≥60 | 11 (25.0) | 33 (75.0) | 5 (11.4) | 39 (88.6) | ||||
| Gender | 0.311 | 0.577 | 0.003 | 0.956 | ||||
| Male | 12 (25.0) | 36 (75.0) | 7 (14.6) | 41 (85.4) | ||||
| Female | 8 (20.0) | 32 (80.0) | 6 (15.0) | 34 (85.0) | ||||
| Histological grade | 0.079 | 0.778 | 1.525 | 0.599 | ||||
| Poor-differentiated | 19 (23.8) | 61 (76.3) | 13 (16.3) | 67 (83.8) | ||||
| Moderately | 1 (12.5) | 7 (87.5) | 0 (0.0) | 8 (100.0) | ||||
| Location | 0.896 | 0.639 | 0.221 | 0.895 | ||||
| Cardia | 1 (11.1) | 8 (88.9) | 1 (11.1) | 8 (88.9) | ||||
| Antrum | 8 (22.2) | 28 (77.8) | 6 (16.7) | 30 (83.3) | ||||
| Gastric body | 11 (25.6) | 32 (74.4) | 6 (14.0) | 37 (86.0) | ||||
| Clinicall stage | 3.697 | 0.063 | 2.179 | 0.357 | ||||
| III | 0 (0.0) | 11 (100.0) | 0 (0.0) | 11 (100.0) | ||||
| IV | 20 (26.0) | 57 (74.0) | 13 (16.9) | 64 (83.1) | ||||
| HER-2 | 0.592 | 0.442 | 0.013 | 0.910 | ||||
| Negative | 19 (24.7) | 58 (75.3) | 12 (15.6) | 65 (84.4) | ||||
| Positive | 1 (9.1) | 10 (90.9) | 1 (9.1) | 10 (90.9) | ||||
| MSI-high | 0.602 | 0.999 | 0.355 | 0.999 | ||||
| Negative | 20 (23.3) | 66 (76.7) | 13 (15.1) | 73 (84.9) | ||||
| Positive | 0 (0.0) | 2 (100.0) | 0 (0.0) | 2 (100.0) | ||||
| CPS | 0.913 | 0.633 | 0.538 | 0.764 | ||||
| <1 score | 20 (23.5) | 65 (76.5) | 13 (15.3) | 72 (84.7) | ||||
| 1 score | 0 (0.0) | 1 (100.0) | 0 (0.0) | 1 (100.0) | ||||
| 10 score | 0 (0.0) | 2 (100.0) | 0 (0.0) | 2 (100.0) | ||||
| Line of therapy | 3.697 | 0.063 | 2.179 | 0.357 | ||||
| Conversion therapy | 0 (0.0) | 11 (100.0) | 0 (0.0) | 11 (100.0) | ||||
| First-line therapy | 20 (26.0) | 57 (74.0) | 13 (16.9) | 64 (83.1) | ||||
| ECOG PS | 51.766 | 0.001 | 43.358 | 0.001 | ||||
| 0 score | 4 (5.7) | 66 (94.3) | 1 (1.4) | 69 (98.6) | ||||
| 1 score | 16 (88.9) | 2 (11.1) | 12 (66.7) | 6 (33.3) |
Note:
Abbreviation used: ORR, objective response rate; DCR, disease control rate; N, number of patients; MSI, Microsatellite Instability; CPS, Combined Positive Score; ECOG PS, Eastern Cooperative Oncology Group Performance Status.