Table 6. Univariate and multivariate analyses of PFS and OS.
| PFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| ECOG = 0 | 2.460 [1.218–4.967] | 0.012 | 3.481 [1.544–7.850] | 0.003 | 3.342 [1.633–6.837] | 0.001 | 4.352 [1.813–10.447] | 0.001 |
| ECOG = 1 | ||||||||
| NLR < 2.84 | 1.245 [0.689–2.249] | 0.467 | 0.743 [0.402–1.373] | 0.343 | ||||
| NLR ≥ 2.84 | ||||||||
| NER < 86.72 | 1.120 [0.584–2.148] | 0.732 | 0.736 [0.379–1.430] | 0.366 | ||||
| NER ≥ 86.72 | ||||||||
| PLR < 82.23 | 0.887 [0.407–1.932] | 0.763 | 0.525 [0.240–1.148] | 0.106 | ||||
| PLR ≥ 82.23 | ||||||||
| LMR < 2.35 | 0.711 [0.395–1.280] | 0.256 | 0.611 [0.334–1.118] | 0.110 | ||||
| LMR ≥ 2.35 | ||||||||
| HALP < 31.17 | 1.158 [0.608–2.204] | 0.655 | 1.235 [0.637–2.395] | 0.532 | ||||
| HALP ≥ 31.17 | ||||||||
| SII < 814.8 | 0.713 [0.365–1.392] | 0.321 | 0.326 [0.157–0.678] | 0.003 | 0.268 [0.109–0.655] | 0.004 | ||
| SII ≥ 814.8 | ||||||||
| BMI (kg/m2) | ||||||||
| Underweight (<18.5) | 0.673 | 0.181 | 0.260 | |||||
| Normoweight (18.5–24.9) | 1.250 [0.661–2.363] | 0.492 | 1.002 [0.540–1.936] | 0.946 | 1.427 [0.715–2.849] | 0.313 | ||
| Overweight (≥25) | 1.551 [0.511–4.708] | 0.438 | 0.373 [0.122–1.139] | 0.083 | 0.545 [0.152–1.946] | 0.350 | ||
| PNI < 46.53 | 0.714 [0.395–1.289] | 0.264 | 0.574 [0.316–1.042] | 0.068 | 0.987 [0.496–1.967] | 0.971 | ||
| PNI ≥ 46.53 | ||||||||
| NLR | 1.703 [0.919–3.154] | 0.091 | 1.459 [0.736–2.892] | 0.279 | 2.222 [1.182–4.179] | 0.013 | 0.995 [0.481–2.058] | 0.989 |
| Decrease | ||||||||
| Increase | ||||||||
| NER | 1.067 [0.554–2.054] | 0.847 | 1.119 [0.584–3.145] | 0.735 | ||||
| Decrease | ||||||||
| Increase | ||||||||
| PLR | 2.304 [1.227–4.325] | 0.009 | 2.660 [1.250–5.658] | 0.011 | 1.979 [1.091–3.590] | 0.025 | 2.479 [1.266–4.854] | 0.008 |
| Decrease | ||||||||
| Increase | ||||||||
| LMR | 1.115 [0.608–2.045] | 0.725 | 1.150 [0.625–2.115] | 0.653 | ||||
| Decrease | ||||||||
| Increase | ||||||||
| HALP | 1.445 [0.788–2.647] | 0.234 | 0.913 [0.500–1.664] | 0.765 | ||||
| Decrease | ||||||||
| Increase | ||||||||
| SII | 1.308 [0.711–2.407] | 0.388 | 1.801 [0.970–3.346] | 0.063 | 1.139 [0.558–2.325] | 0.721 | ||
| Decrease | ||||||||
| Increase | ||||||||
| PNI | 1.744 [0.926–3.286] | 0.085 | 1.568 [0.791–3.106] | 0.198 | 1.400 [0.755–2.595] | 0.285 | ||
| Decrease | ||||||||
| Increase | ||||||||
Note:
Abbreviation used: PFS, progression-free survival; OS, overall survival; HR, Hazard Ratio; CI, Confidence Interval; ECOG PS, Eastern Cooperative Oncology Group Performance Status; NLR, neutrophil count to lymphocyte count ratio; NER, neutrophil count to eosinophil count ratio; PLR, platelet count to lymphocyte count ratio; LMR, lymphocyte count to monocyte count ratio; HALP, the hemoglobin, albumin, lymphocyte and platelet score; SII, systemic immune-inflammation index; BMI, Body Mass Index; PNI, prognostic nutritional index.