Table 2.

Comparing the estimated monetary expenses of a conventional trial to an enrichment trial, assuming our ‘common predictor’ classifier was used for patient stratification employing a classifier threshold of 0.65

	Conventional trial	Enrichment trial	Difference
Screened patients	5967	6834	867
Screening costs	$41 512 419	$47 544 138	$6 031 719
Recruited patients	1796	1135	−661
Treatment costs	$47 594 000	$30 077 500	−$17 516 500
Total adverse events	593	375	−218
Serious adverse events	227	144	−83
ARIA cases	278	176	−102
ARIA monitoring costs	$428 120	$271 040	−$157 080
Total costs	$89 534 539	$77 892 678	−$11 641 861