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[Preprint]. 2024 Dec 11:2024.12.09.24317629. [Version 1] doi: 10.1101/2024.12.09.24317629

Figure 4. Molecular modeling of ADA2 variants G47A, G47R, G47V, G47W, R169Q, E328K, H424N and Y453C.

Figure 4.

A. Comparative plots of the different mutations which displays the variability of B-factor values along the protein backbone compared to the wild target. Blue backbones represent lower fluctuations compared to the wild target, red backbones represent higher fluctuations. B. Zoom-in of residue R169 in the wild target protein. R169 is shown in magenta. Polar and aromatic interactions are shown as dashed lines. C. Zoom-in of residue E328 in the wild target protein. E328 is shown in magenta. Polar interactions are shown as dashed lines. D. Zoom-in of residue Y453 in the wild target protein. Y453 is shown in magenta. Polar interactions are shown as dashed lines.