Table 1.

Protease activity and cleavage products in the hippocampus and associated brain regions

		Male		Female
		Normoxia	CIH	Normoxia	CIH
CA3	Calpain Activity	108.96 ± 54.12	113.73 ± 29.26	138.61 ± 66.66	135.91 ± 80.75
	Caspase-3 Activity	30.02 ± 21.12	37.33 ± 19.92	45.87 ± 31.79	32.38 ± 18.37
	Calpain Cleaved Spectrin	113.05 ± 84.41	132.23 ± 93.09	108.40 ± 43.42	140.83 ± 59.18
	Caspase-3 Cleaved Spectrin	27.48 ± 22.37	42.98 ± 40.94	29.65 ± 8.46	37.81 ± 24.86
CC	Calpain Activity	38.96 ± 16.30	48.31 ± 15.88	45.90 ± 16.12	35.06 ± 9.17
	Caspase-3 Activity	10.04 ± 6.14	13.66 ± 9.01	12.25 ± 6.48	14.02 ± 8.13
	Calpain Cleaved Spectrin	38.39 ± 19.86	43.37 ± 15.80	54.20 ± 20.17	38.98 ± 17.08
	Caspase-3 Cleaved Spectrin	9.97 ± 6.62	14.25 ± 7.71	13.13 ± 5.16	13.43 ± 5.66
LC	Calpain Activity	54.79 ± 28.30	46.16 ± 28.76	123.57 ± 101.08	47.05 ± 21.70
	Calpain Cleaved Spectrin	47.32 ± 36.33	72.45 ± 40.40	29.85 ± 15.75	105.24 ± 98.68

Calpain and caspase-3 activity represent % of protease cleaved spectrin to uncleaved spectrin (250 kD). Calpain cleaved spectrin (150 kD) and caspase-3 cleaved spectrin (120 kD) expression normalized to β-actin. All values presented as mean ± SD. Analyzed by 2-way ANOVA with Fisher’s LSD multiple comparisons tests. CC: Cerebellar cortex; CIH: Chronic intermittent hypoxia; LC: Locus coeruleus.