Figure 1:

M. avium MAC 101 (A) and MAC 104 (B) burden in the lungs of BALB/c mice. Time point week −4 represents 24 h after infection with respective strain via the aerosol route. Time point week 0 represents conclusion of four weeks of infection and the day of antibiotic treatment initiation. Time points week- 1, 4 and 8 represent the end of 1, 4 and 8 weeks of once daily oral administration of phosphate-buffered saline (PBS), 100 mg/kg clarithromycin (CLR), 25 mg/kg clofazimine (CFZ), and 20 mg/kg rifabutin (RFB). Mean CFU per lung and standard deviation are shown (n=5 per time point per group). (C) Gross pathology of the lungs of mice infected with MAC 104 from each treatment group, two mice per group at the conclusion of treatment (week 8) are shown.