Figure 2:

(A) M. avium MAC 101 burden in the lungs of BALB/c mice. Time point week −4 represents 24 h after infection via the aerosol route. Time point week 0 represents conclusion of four weeks of infection and the day of antibiotic treatment initiation. Time points week- 1, 4 and 8 represent the end of 1, 4 and 8 weeks of once daily oral administration of phosphate-buffered saline (No treatment), 100 mg/kg clarithromycin (CLR), 25 mg/kg bedaquiline (BDQ) and 25 mg/kg clofazimine (CFZ). Mean CFU per lung and standard deviation are shown (n=5 per time point per group). (B) Percentage reductions in the mean MAC 101 burden in the lungs of mice treated with 100 mg/kg clarithromycin + 25 mg/kg clofazimine + 25 mg/kg bedaquiline during the first week, second-fourth week, and fifth-eighth week are shown. (C) Gross pathology of the lungs of mice infected with MAC 101 from each treatment group, two mice per group, at the conclusion of treatment (week 8) are shown.