Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Dec 20;10(51):eadp9333. doi: 10.1126/sciadv.adp9333

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 1. — (A) Bioinformatics analysis of the primary amino acid sequences of all nonstructural proteins of HuNoV GII.4 to predict LLPS propensity using DeePhase. The dotted black line indicates the threshold LLPS score of proteins to undergo LLPS. (B and C) The disorder prediction of GII.4 RdRp primary amino acid sequence using bioinformatics tools (B) PONDR and (C) IUPred2. The dotted black line in both panels indicates the threshold disorder score and the dashed pink oval shows the predicted disordered N-terminal region. (D and E) The oligomeric state of GII.4 RdRp analyzed using (D) size exclusion chromatography and (E) sedimentation velocity analytical ultracentrifugation. (F) A cartoon representation of the crystal structure of GII.4 RdRp showing the disordered/flexible N-terminal region colored in pink.