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. 2024 Dec 20;10(51):eadp9333. doi: 10.1126/sciadv.adp9333

Fig. 3. Phase separation of GII.4 RdRp is modulated by PEG-3350 concentration, pH, and salt concentration.

Fig. 3.

Effect of (A) protein and PEG-3350 concentrations, (C) protein concentrations and pH, and (E) protein and salt concentrations on the phase separation of RdRp was assessed by measuring the turbidity of the samples at an optical density of 350 nm. (B, D, and F) A phase diagram of RdRp at (B) protein and PEG-3350 concentrations, (D) protein concentrations and pH, and (F) protein and salt concentrations constructed from the confocal microscopy images. The green boxes indicate LLPS (condensate state), and the white boxes indicate no LLPS (soluble state).