Tabla 2:
Resultados de los estudios de genotipado de nuestra población.
| Gen DPYD | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | rs3918290 (*2) | rs67376798-DPYD*14 | Rs55886062 (*13) | rs75017182 G>C | rs56038477 | rs115232898 | rs1801158 | rs1801160 | rs1801266 | rs1801268 | rs59086055 | rs777425216 | rs78060119 | rs80081766 | rs9996584 |
| Wild type | 100 | 99 | 100 | 96.5 | 96.5 | 100 | 95.3 | 92.9 | 100 | 100 | 100 | 100 | 100 | 100 | 31.8 |
| HetMut | 0 | 1 | 0 | 3.5 | 3.5 | 0 | 4.7 | 7.1 | 0 | 0 | 0 | 0 | 0 | 0 | 51.8 |
| HomMut | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16.4 |
| Gen GSTP | Gen XPC | Gen ERCC1 | Gen XRCC1 | Gen ERCC1 | Gen SEMAC | Gen C8orf34 | UGT1A1 | |||
|---|---|---|---|---|---|---|---|---|---|---|
| rs1695 | rs2228001 | rs3212986 | rs25487 | rs11615 | rs7779029 | rs1517114 | rs4148323 | *1/*1 | 39.4 | |
| Wild type | 8.2 | 30.6 | 2.4 | 41.2 | 9.4 | 1.2 | 14.1 | 100 | *28/*28 | 19.7 |
| HetMut | 34.1 | 54.1 | 37.6 | 44.7 | 45.9 | 14.1 | 41.2 | 0 | *1/*28 | 37.9 |
| HomMut | 56.5 | 15.3 | 60.0 | 41.2 | 44.7 | 84.7 | 44.7 | 0 | *1/*36 | 3.0 |
Los estudios se expresan en % de pacientes que expresan el genotipo salvaje (wild type), heterocigoto mutado (HetMut) y homocigoto mutado (HomMut). De modo independiente se muestran los resultados para el gen UGT1A1.