TABLE 1.
Clinical and Pathological Characteristics of the Whole Cohort and Patients Who Developed Recurrence
| Characteristics | N | Total | Recurrence | P | |
|---|---|---|---|---|---|
| Yes | No | ||||
| Age, yr, mean (SD) | 1611 | 68.8 (11.5) | 67.1 (11.8) | 70.7 (10.9) | 0.263 |
| Gender | 1611 | 0.021 | |||
| Male | 883 (54.9%) | 54 (6.1%) | 829 (93.9%) | ||
| Female | 728 (45.2%) | 26 (3.6%) | 702 (45.9%) | ||
| BMI | 1097 | 0.234 | |||
| Underweight/normal | 502 (45.8%) | 20 (4.0%) | 481 (96%) | ||
| Overweight/obese | 595 (54.2%) | 37 (6.2%) | 558 (93.8%) | ||
| Charlson Comorbidity Index | 1516 | 0.160 | |||
| ≤4 | 758 (50.0%) | 32 (4.2%) | 726 (95.8%) | ||
| >4 | 758 (50.0%) | 45 (5.9%) | 713 (94.1%) | ||
| Site | 1611 | 0.305 | |||
| Midgut | 816 (50.7%) | 36 (4.4%) | 780 (95.6%) | ||
| Hindgut | 795 (49.3%) | 44 (5.5%) | 751 (94.5%) | ||
| CEA, median (IQR) | 1006 | 2 (2) | 2.5 (3.5) | 1.8 (1.8) | 0.007 |
| pT | 1611 | 0.013 | |||
| pT1 | 617 (38.3%) | 20 (3.2%) | 597 (96.8%) | ||
| pT2 | 994 (61.7%) | 60 (6.0%) | 934 (94%) | ||
| Tumor diameter, mm, mean (SD) | 1190 | 31.2 (16.8) | 40.2 (19.1) | 30.6 (16.7) | <0.001 |
| Macroscopic type | 885 | 0.931 | |||
| Sessile | 470 (53.1%) | 16 (3.4%) | 454 (96.6%) | ||
| Pedunculated | 307 (34.7%) | 10 (3.3%) | 297 (96.7%) | ||
| LST | 108 (12.2%) | 4 (3.7%) | 104 (96.3%) | ||
| Histology | 1611 | 0.400 | |||
| Adenocarcinoma | 1483 (92.0%) | 76 (5.1%) | 1407 (94.9%) | ||
| Mucinous/SR | 128 (8.0%) | 4 (3.1%) | 124 (96.9%) | ||
| Grading | 1576 | 0.552 | |||
| G1–G2 | 1425 (90.4%) | 69 (4.8%) | 1356 (95.2%) | ||
| G3 | 151 (9.6%) | 9 (6.0%) | 142 (94%) | ||
| LVI | 1478 | 0.01 | |||
| Present | 305 (20.6%) | 22 (7.2%) | 283 (92.8%) | ||
| Absent | 1173 (79.4%) | 42 (3.6%) | 1131 (96.4%) | ||
| PNI | 1426 | 1.00 | |||
| Present | 53 (3.7%) | 2 (3.8%) | 51 (96.2%) | ||
| Absent | 1373 (96.3%) | 56 (4.1%) | 1317 (95.9%) | ||
P value refers to the comparison between patients who developed recurrence and patients who did not. Categorical variables are reported as count (%) while quantitative variable as mean (SD) or median (IQR) as appropriate.
Statistically significant P values are highlighted in bold.
BMI indicates body mass index; IQR, interquartile range; LST, laterally spreading tumor; LVI, lymphovascular invasion; PNI, perineural invasion; SR, signet ring.