TABLE 3.

Influence of Individual, Tumor, and Surgical Characteristics on Tumor Recurrence

Characteristics	Unadjusted Hazard Ratio (95% Confidence Interval)	Unadjusted P Value	Adjusted Hazard Ratio (95% Confidence Interval)	Adjusted P Value
Gender (women vs men)	0.57 (0.35–0.90)	0.017	0.54 (0.31–0.94)	0.030
Age	0.99 (0.97–1.01)	0.274	0.98 (0.96–1.01)	0.229
Charlson index
Score<4	1 (reference)		1 (reference)
Score>4	1.46 (0.93–2.30)	0.100	1.21(0.64–2.32)	0.558
Missing	0.78 (0.24–2.55)	0.681	0.39 (0.11–1.42)	0.155
pT (pT2 vs pT1)	1.92 (1.16–3.18)	0.012	1.59 (0.84–3.02)	0.157
Tumor diameter
≤20 mm	1 (reference)		1 (reference)
21–30 mm	3.40 (1.23–9.45)	0.019	2.94 (0.89–9.6)	0.077
31–40 mm	4.84 (1.77–13.2)	0.002	5.83 (1.89–18.05)	0.002
>40 mm	6.06 (2.24–16.43)	0.000	6.00 (1.90–18.96)	0.002
Missing	5.02 (1.94–13.00)	0.001	4.09 (1.34–12.50)	0.013
LVI (yes vs no)	2.07 (1.23–3.46)	0.006	2.08 (1.90–3.62)	0.010
CEA level (>5 vs ≤5)	2.12 (1.13–4.00)	0.020	3.10 (1.48–6.49)	0.003
Missing	1.24 (0.77–2.01)	0.374	1.32 (0.73–2.40)	0.363
Analyzed lymph nodes (≥ 12 vs <12)	0.75 (0.45–1.27)	0.285	0.43 (0.24–0.77)	0.004
Type of resection (partial vs anatomic)	2.44 (1.26–4.74)	0.008	1.55 (0.47–5.10)	0.467

Hazard ratios and P values were obtained by univariable and multivariable Cox regression model. A total of 1427 patients were included in the model.

Statistically significant P values are highlighted in bold.

LVI indicates lymphovascular invasion.