Table 1.

Overall features of AE reports of MM patients in openFDA from 2004 to 2022.

Region	Number (%)	#M/F (Age: M/F)
NA	330,187 (82.9%)	1.1 (68.9/69.4)
EU	43,586 (10.9%)	1.3 (67.4/68.0)
AS	17,611 (4.4%)	1.2 (68.6/69.8)
OC	4265 (1.1%)	1.4 (67.8/67.9)
LA	2490 (0.6%)	1.0 (64.8/65.6)
AF	394 (0.1%)	1.4 (60.2/59.4)
Reporting year	Total case number	%
2004–2011	24,381	6.16%
2012–2014	40,447	10.23%
2015	38,514	9.74%
2016	30,871	7.80%
2017	35,025	8.86%
2018	34,334	8.68%
2019	39,252	9.92%
2020	43,907	11.10%
2021	63,084	15.95%
2022	45,722	11.56
Adverse events	Number	%
Cardiac	20,564	5.20%
Neoplasm	41,660	10.53%
Renal	17,056	4.31%
Vascular	24,194	6.12%