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. 2024 Dec 20;7:1686. doi: 10.1038/s42003-024-07406-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — A UAMP clustering of 3483 AC cells isolated from the pancreas of neonatal and adult goats. Colored according to the assigned subtypes. B Heatmap shows the expression of the selected 8 candidates (rows) between the two AC subtypes (columns) by multi-omics analysis. The colors in the heatmap correspond to standardized log₂ expression values, where each heatmap cell contains the distribution of values across the cells in each cluster. The top bar indicates the assigned subtype identity. C PAGA abstracted graph showing the most probable subgraph representing the AC data manifold. Each node corresponds to a cluster, the size of nodes is proportional to the number of cells in each cluster and edges indicate potential routes of cell transitions between them. Trajectory analysis of acinar cells colored according to pseudotime (D) and AC subtypes (E). F Expression of pancreatic digestive enzyme related genes along pseudotime. G Expression of exocytosis related genes along pseudotime.