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. 2024 Dec 20;7:1574. doi: 10.1038/s42003-024-07257-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Segmentation of different spatial bands away from the wound boundary. Bands 1 to 4 are concentric to the wound boundary and have a width of 0.5 mm. Band 5 covers the remaining pixels outside band 4. The full FOV is 7 mm × 7 mm. b Heatmap with colors indicating median sO₂ within each band. Pixel values within the wound area were discarded. c Spatial profile of microvascular sO₂ changes. Box plot shows the spatial changes at day 4 (n = 6 wounds from 4 mice). Line plot presents an overview of the spatial changes at all time points. Baseline measurement was taken on healthy skin of the same group of mice. d Spatial profile of vessel diameter changes. e Spatial profile of vessel tortuosity changes. Asterisks (*) indicate significant differences (p < 0.05). Error bars in line graphs are defined as 95% confidence intervals.