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. 2024 Dec 20;41(1):3. doi: 10.1007/s10565-024-09946-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — miR-21-Exo restored the estrous cycle and hormones in chemically-induced ovarian insufficiency rats. (A) Schematic schematic illustrating the animal experimental design. (B) Intraperitoneal injection of DiR-labeled Exo or miR-21-Exo resulted in in vivo metabolism observed through live animal imaging. (C) Ovarian frozen sections showed uptake of DiR fluorescently labeled exosomes by the ovaries. (D) Representative estrous cycles of rats exhibiting either regular or interrupted estrous cycles within each group. (E) The levels of serum sex hormones E₂, FSH, and AMH were measured using ELISA (n = 4)