Figure 2.

Optogenetic inhibition of the LC does not affect anxiety-like behavior or locomotion. (A) Illustration of the open field arena. The unshaded region was considered the “center” of the open field. (B) Mean percentage of time spent in the center (+/− SEM) during the open field test. (C) Mean number of entries into the center of the open field (+/− SEM). (D) Mean total distance moved in the open field (+/− SEM). (E) Illustration of the elevated plus maze. The unshaded arms were “open” because they did not have walls along the sides. (F) Mean percentage of total time spent in the open arms of the elevated plus maze (+/− SEM). (G) Mean number of entries into the open arms of the elevated plus maze (+/− SEM). (H) Mean total distance traveled in the elevated plus maze (+/− SEM). (I) Stimulation parameters for optogenetic inhibition during testing. Circles indicate males, while triangles indicate females. No significant differences were seen between sham-eYFP and sham-ArchT in any of the tests.