Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Dec 6;15:1415317. doi: 10.3389/fimmu.2024.1415317

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Akimov, Tychinin, Antonova, Shaymardanov, Voronina, Deinichenko, Fateev, Yudin, Yudin, Mukhin, Romanova, Nekrasova, Zhdanova, Tsypkina, Vladimirov, Makhotenko, Keskinov, Kraevoy, Snigir, Svetlichnyy and Skvortsova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Master regulators of Mon IFI30 cell state. (A) Graph of the CellOracle gene network containing Mon IFI30 marker genes and core transcriptional regulators. The nodes are colored according to the regulatory TF. The size of a node reflects the number of incoming and outcoming connections for the regulators. (B) Heatmap with the TF perturbation response. The barplot on top of the heatmap shows an absolute expression shift across all genes for every perturbation. In silico perturbations for single or multiple TFs (mentioned at the bottom of the plot). (C) Scatterplot of in CD14 monocyte expression values predicted in Mon IFI30 after joint knockdown of FOSL2, MITF, and ATF3. (D) Lineplot showing changes in the expression of the Mon IFI30 marker genes after joint in silico knockdown of FOSL2, MITF, and ATF3. (E) UMAP plot of monocytes across the study conditions with the direction of the vector fields upon joint perturbation of the FOSL2, MITF, and ATF3 TFs.