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. 2024 Dec 20;22:1125. doi: 10.1186/s12967-024-05917-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Napabucasin-PLGA NPs downregulate p-STAT3^Try705 levels and stemness characteristics of HCC cells. A Immunoblot showed STAT3 and p-STAT3^Try705 levels in Huh7 cells treated with different concentrations of Napabucasin-PLGA NPs. B The mRNA levels of stemness markers in HCC cells treated with Napabucasin (1 μM) or Napabucasin-PLGA NPs (1 μM) for 12 h. C HCC cells were treated with different concentrations of Napabucasin or Napabucasin-PLGA NPs, and the colony formation was detected on day 15. D HCC cells were treated with Napabucasin or Napabucasin-PLGA NPs, and the sphericity was detected on day 10. Napa, Napabucasin; Napa NPs, Napabucasin-PLGA NPs. Data are shown as mean ± SD from three independent experiments. Compared with 0 μM, one-way ANOVA with Tukey test. *p < 0.05, **p < 0.01