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. 2024 Dec 20;14:151. doi: 10.1186/s13578-024-01332-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Potential MES-like GBM specific therapeutic agents: Trametinib and Dasatinib. A The left graph is a Venn diagram, where the intersection represents drugs that meet both screening criteria; the right graph is a scatter plot, where each point represents a drug, the x-axis represents the correlation between IC50 and M1 scores, and the y-axis represents the logFC from the differential analysis of the pseudo-bulk high and low M1 groups. The dashed line is located at −0.1. B Boxplot of IC50 for 13 kinds of drugs in the pseudo-bulk high and low M1 groups. C Beyondcell UMAP of tumor cells grouped by high and low M1. D The 4 squares plot is a scatter plot of the residual mean and the switch point of the high M1 group cells. The left and right sides respectively display the drugs with low/high sensitivity to selected cells. E–F Evaluating the drug sensitivity of tumor cells to Dasatinib and Trametinib based on Beyondcell. G-H Histogram of bc score distribution for 4 subtypes of tumor cells