Fig. 6.

The gene regulatory network specific to the MES-like GBM cells. A Distribution of the 9 regulatory modules of transcription factors in malignant cells. B Table of six representative transcription factors and their binding motifs for nine regulatory modules. C UMAP plot of the activity of nine regulatory modules in the M1 high and low groups. D Activity scores of 9 regulatory modules in 4 subtypes of GBM cells. E Network diagram of transcription factors and target genes within regulatory module 8. F Variance decomposition results of 11 transcription factors in regulatory module 8 across 4 GBM tumor subtypes