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. 2024 Dec 20;14:151. doi: 10.1186/s13578-024-01332-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Essential and specific regulation of MES-like cells by the transcription factor CEBPG. A-B Lasso regression analysis was performed to identify 9 M1-related risk genes. C The quantitative PCR (qPCR) results for the CEBPG gene expression in normal human astrocytes (NHA) and GBM cell lines (U87-MG and U118-MG). D Immunohistochemistry results for CEBPG in normal cortical tissue, low-grade gliomas, and high-grade gliomas derived from the HPA database. E UMAP plot of integrated snATAC-seq (GSE240822) for malignant tumor cells from GBM samples. F The functional activity of two binding motifs (MA1636.1 and MA0838.1) of the CEBPG transcription factor in GBM cells. G Boxplot of enrich score of two binding motifs (MA1636.1 and MA0838.1) of CEBPG in 4 GBM subgroups. H Genome footprint plot showing the enrichment scores of Tn5 insertions for the CEBPG transcription factor in 4 subtypes of GBM cells