Table 1.

The Results of Bidirectional MR Analyses

Exposure	Outcome	No. of SNPs	Methods			OR (95% CI)	β (SE)			p
The forward MR analyses
Depression	CS	148	IVW MR‐Egger Weighted median Weighted mode Simple mode			1.322257994 (1.205–1.441) 1.089480632 (0.959–1.238) 1.019119293 (0.995–1.044) 1.082707463 (1.011–1.152) 1.03446078 (0.925–1.104)	0.0220139 (0.008806643) 0.085701098 (0.065198879) 0.018938816 (0.012411153) -0.007319258 (0.035005598) -0.011606313 (0.034064884)			0.012430116 0.192228459 0.127021989 0.83487385 0.734151358
The reverse MR analyses
CS	Depression	58		IVW MR‐Egger Weighted median Weighted mode Simple mode	1.426346001 (1.236–1.650) 0.427503874 (0.135–1.349) 1.229136267 (0.962–1.571) 0.061291714 (0.707–2.178) 0.05516086 (0.723–2.227)		0.203631218 (0.085889038) -0.84979192 (0.586491465) 0.206311701 (0.125182923) 0.216221276 (0.286920494) 0.238285021 (0.286961345)		0.017746563 0.153031696 0.099335881 0.454250535 0.409853987

Abbreviations: CI, confidence interval; IVW, inverse variance weighted; LTL, leukocyte telomere length; MR, Mendelian randomization; OR, odds ratio; SNPs, single‐nucleotide polymorphisms.