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. 2024 Dec 17;17:11175–11193. doi: 10.2147/JIR.S485165

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© 2024 Wu et al.

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Schematic show that the mechanism of hsa_circ_100791 promote the progression of allergic rhinitis. Hsa_circ_100791 could increase the expression of TRIM13 by sponging miR-487b-5p, and consequently activate the NF-κB signaling pathway, and upregulates the expression of pro-inflammatory factors (IL-4, IL-5 and IL-13, IL-1β, IL-6, IL-8, IL-17, IL-18, IL-33 and TNF-α), inhibits the expression of Th1-related inflammatory factors (IL-2 and IFN-γ), and ultimately promotes the the inflammatory response of AR.