Table 2.
Crude incidence rate, and cox proportional hazard analysis for psoriasis
| Event, n (%) | IR (95% CI) per 1000 person-years |
Adjusted HR (95% CI) |
P Value | PAF (%) (95% CI) |
|
|---|---|---|---|---|---|
| CRP | |||||
| Log-CRP per 1-SD increase | 4160/420,040 (0.99%) | 0.81 (0.78, 0.83) | 1.16 (1.12, 1.20) | < 0.0001 | - |
| < 2 mg/dL | 2327/273,012 (0.85%) | 0.69 (0.66, 0.72) | Reference | Reference | |
| ≥ 2 mg/dL | 1833/147,028 (1.25%) | 1.03 (0.98, 1.08) | 1.26 (1.18, 1.34) | < 0.0001 | 7.65 (5.70, 9.60) |
| Q1 | 748/103,526 (0.72%) | 0.58 (0.54, 0.62) | Reference | Reference | |
| Q2 | 933/106,014 (0.88%) | 0.71 (0.67, 0.76) | 1.11 (1.01, 1.22) | 0.0355 | 2.00 (0.28, 3.72) |
| Q3 | 1106/105,216 (1.05%) | 0.86 (0.81, 0.91) | 1.24 (1.13, 1.37) | < 0.0001 | 4.57 (2.74, 6.40) |
| Q4 | 1373/105,284 (1.30%) | 1.08 (1.02, 1.14) | 1.45 (1.31, 1.59) | < 0.0001 | 8.68 (6.37, 11.00) |
| P-trend < 0.0001 | |||||
| PRS | |||||
| Per 1 score increase | 4160/420,040 (0.99%) | 0.81 (0.78, 0.83) | 1.32 (1.29, 1.36) | < 0.0001 | - |
| [0%, 33.3%] | 999/139,876 (0.71%) | 0.58 (0.55, 0.62) | Reference | Reference | |
| (33.3%, 66.6%] | 1291/139,870 (0.92%) | 0.75 (0.71, 0.79) | 1.29 (1.19, 1.40) | < 0.0001 | 6.64 (4.63, 8.65) |
| (66.6%, 100%] | 1870/140,294 (1.33%) | 1.09 (1.04, 1.14) | 1.87 (1.73, 2.02) | < 0.0001 | 19.97 (17.56, 22.39) |
| P-trend < 0.0001 |
CRP, C-reactive protein; PRS: polygenic risk score; IR, incidence rate; CI, confidence interval; HR, hazard ratio; PAF, population attributable fraction
Adjustment for age, sex, ethnicity, annual income, smoking status, drinking status, Body mass index (BMI), diabetes mellitus, dyslipidemia, and hypertension history