Table 3.

Combined effects of CRP, PRS and the risk of Psoriasis

Outcomes	PRS levels (HR, 95% CI)				RERI ‡		P for interaction §
	Low PRS	Moderate PRS	High PRS		Moderate PRS	High PRS
CRP
< 2 mg/dL	1.00	1.16 (1.04, 1.29)	1.68 (1.52, 1.86)				0.0028
≥ 2 mg/dL	1.04 (0.91, 1.18)	1.55 (1.38, 1.74)	2.24 (2.01, 2.49)		0.37 (0.17, 0.56)	0.51 (0.30, 0.73)

Adjustment for age, sex, ethnicity, annual income, smoking status, drinking status, Body mass index (BMI), diabetes mellitus, dyslipidemia, and hypertension history

HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; PRS: polygenic risk score; RERI, relative excess risk due to interaction

‡: The estimates of RERI were calculated based on the reference group with low CRP and low PRS

§: Likelihood tests was applied to test the significance of interaction term by comparing the model with and without the interaction term