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. 2024 Nov 9;68(1):128–151. doi: 10.1007/s00125-024-06307-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 9 — (a–d) Early and late apoptosis were measured as percentage (%) of Annexin-V and PI-positive cells, respectively, in WFS1 and WFS1wt/757A>T iBeta after 50 nmol/l TG or inflammatory cytokine exposure. Data are plotted as mean ± SD. n=3–5. **p<0.01, ***p<0.001 (by two-way ANOVA with Dunn–Šídák correction). (e, f) Gene expression of the splicing factors UPF1 and SMG7 in WFS1 and WFS1wt/757A>T iBeta upon TG or inflammatory cytokine treatment at the indicated times. Data are expressed as fold change over the untreated control. Data are expressed as mean ± SD; n=3. **p<0.01, ***p<0.001 (by two-way ANOVA with Dunn–Šídák correction). (g, h) Relative quantification of AS isoforms in WFS1 iBeta upon treatment for 8 h and 16 h with TG (g) or treatment for 48 h with inflammatory cytokines (h). Data are plotted as mean ± SD. n=3 independent experiments. **p<0.01, ***p<0.001 (by two-way ANOVA with Dunn–Šídák correction)