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. 2024 Dec 21;74(1):30. doi: 10.1007/s00262-024-03871-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Contrasting Kaplan–Meier curves (irAEs vs. no irAEs) derived from the original cohort (naive analysis; solid lines) versus Kaplan–Meier curves from the emulated cohort (TTE approach; dashed lines). Red—no irAE group. Blue—irAE group. Numbers at risk taken from the naïve analysis. (P values by log-rank test. PFS: p < 0.001 for original cohort; p = 0.04 for emulated cohort; OS: p < 0.001 for original cohort; p = 0.2 for emulated cohort)