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. 1974 Jun;139(3):603–607. doi: 10.1042/bj1390603

Uptake and release of ferritin iron. Surface effects and exchange within the crystalline core

Terence G Hoy 1, Pauline M Harrison 1, Mohammad Shabbir 1
PMCID: PMC1166324  PMID: 4855331

Abstract

The uptake and subsequent release of iron by apoferritin and ferritin was studied by using labelled iron (59Fe). The experimental results are consistent with predictions arising from a model system developed in the interpretation of previous experiments. In this model, uptake and release of ferritin iron is controlled by the available surface area of the small crystalline particles of hydrous ferric oxide found within the ferritin molecule. Evidence is also presented for the exchange of Fe3+ ions among the various cation sites within these crystallites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryce C. F., Crichton R. R. The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification. Biochem J. 1973 Jun;133(2):301–309. doi: 10.1042/bj1330301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Crewe A. V., Wall J. A scanning microscope with 5 A resolution. J Mol Biol. 1970 Mar;48(3):375–393. doi: 10.1016/0022-2836(70)90052-5. [DOI] [PubMed] [Google Scholar]
  3. FARRANT J. L. An electron microscopic study of ferritin. Biochim Biophys Acta. 1954 Apr;13(4):569–576. doi: 10.1016/0006-3002(54)90376-5. [DOI] [PubMed] [Google Scholar]
  4. Fischbach F. A., Anderegg J. W. An x-ray scattering study of ferritin and apoferritin. J Mol Biol. 1965 Dec;14(2):458–473. doi: 10.1016/s0022-2836(65)80196-6. [DOI] [PubMed] [Google Scholar]
  5. Haggis G. H. The iron oxide core of the ferritin molecule. J Mol Biol. 1965 Dec;14(2):598–602. doi: 10.1016/s0022-2836(65)80210-8. [DOI] [PubMed] [Google Scholar]
  6. Harrison P. M., Fischbach F. A., Hoy T. G., Haggis G. H. Ferric oxyhydroxide core of ferritin. Nature. 1967 Dec 23;216(5121):1188–1190. doi: 10.1038/2161188a0. [DOI] [PubMed] [Google Scholar]
  7. Hoy T. G., Harrison P. M., Shabbir M., Macara I. G. The release of iron from horse spleen ferritin to 1,10-phenanthroline. Biochem J. 1974 Jan;137(1):67–70. doi: 10.1042/bj1370067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LOEWUS M. W., FINEBERG R. A. The incorporation of iron by apoferritin. Biochim Biophys Acta. 1957 Nov;26(2):441–443. doi: 10.1016/0006-3002(57)90036-7. [DOI] [PubMed] [Google Scholar]
  9. Macara I. G., Hoy T. G., Harrison P. M. The formation of ferritin from apoferritin. Catalytic action of apoferritin. Biochem J. 1973 Oct;135(2):343–348. doi: 10.1042/bj1350343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Macara I. G., Hoy T. G., Harrison P. M. The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake. Biochem J. 1972 Jan;126(1):151–162. doi: 10.1042/bj1260151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Turner J. C. Triton X-100 scintillant for carbon-14 labelled materials. Int J Appl Radiat Isot. 1968 Jul;19(7):557–563. doi: 10.1016/0020-708x(68)90065-3. [DOI] [PubMed] [Google Scholar]
  12. Wyllie J. C., Kaufman N. A study of storage iron in the pregnant rat. Br J Haematol. 1971 Mar;20(3):321–327. doi: 10.1111/j.1365-2141.1971.tb07042.x. [DOI] [PubMed] [Google Scholar]

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