Table 2.
Complications after unrelated and sibling donor transplantation undergoing different conditioning regimen
| Variables, n (%) | Unrelated donor transplantation | Sibling donor transplantation | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CCR group (n = 53) |
NCR group (n = 60) |
OR/ difference value |
95% CI | p | CCR group (n = 65) |
NCR group (n = 28) |
OR/ difference value |
95% CI | p | |
| Mixed chimerism | 5(9.4) | 1(1.7) | 0.247 | 0.029–2.074 | 0.198 | 27(41.5) | 2(7.1) | 0.112 | 0.023–0.554 | 0.007* |
| GVHD | ||||||||||
| Acute, grade II-IV | 23(43.4) | 28(46.7) | 1.355 | 0.611–3.007 | 0.455 | 15(23.1) | 3(10.7) | 0.460 | 0.118–1.798 | 0.264 |
| Chronic | 10(18.9) | 15(25.0) | 1.380 | 0.538–3.540 | 0.503 | 8(12.3) | 2(7.1) | 0.388 | 0.071–2.125 | 0.275 |
| Fungal infection | 14(26.4) | 3(5.0) | 0.164 | 0.048–0.560 | 0.004 | 14(21.5) | 1(3.6) | 0.123 | 0.013–1.198 | 0.071 |
| Bacteremia | 6(11.3) | 4(6.7) | 0.716 | 0.185–2.774 | 0.629 | 8(12.3) | 3(10.7) | 0.634 | 0.137–2.932 | 0.560 |
| PRES | 5(9.4) | 2(3.3) | 0.356 | 0.069–1.836 | 0.217 | 5(7.7) | 0(0) | 0.077 | 0.012–0.142 | 0.314▲ |
| PTLD | 2(3.8) | 2(3.3) | 1.263 | 0.155–10.314 | 0.828 | 0(0) | 0(0) | |||
| AIHA | 8(15.1) | 0(0) | 6.763 | 0.055–0.247 | 0.006▲ | 15(23.1) | 0(0) | 0.231 | 0.129–0.333 | 0.014▲ |
Abbreviations: CCR, conventional conditioning regimen; NCR, novel conditioning regimen; ANC, absolute neutrophil count; PLT, blood platelet; GVHD, graft versus host disease; AIHA, autoimmune hemolytic anemia; PRES, posterior reversible encephalopathy syndrome; PTLD, posttransplant lymphoproliferative disorders
*The differences are statistically significant. The difference analysis for complications except AIHA and PRES between two groups was performed using the propensity score and Cochran-Mantel-Haenszel test
▲The difference analysis for AIHA and PRES between two groups was performed using the chi-square test