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. 2024 Dec 22;22:1137. doi: 10.1186/s12967-024-05881-6

Table 3.

Drugs and compounds associated with ferroptosis for neurodegenerative diseases treatment

Drugs Inhibitor Target References
Lipid peroxidation inhibitors Zileuton Inhibit 5-LOX [166, 167]
Antioxidants Ferrostatin-1 ROS scavenger, increase GSH level, [168]
Antioxidants SRS11–92 ROS scavenger, reduce lipid peroxides [169, 170]
Antioxidants SRS-16–86 ROS scavenger, reduce lipid peroxide [171, 172]
Lipid soluble antioxidant Vitamin E GPX4 [165]