Figure 11.

Inhibiting HIF-1α reversed the protective effects of ciprofol on Fe²⁺ accumulation and mitochondrial damage in mice with myocardial I/R injury. BAY87-2243 (9 mg/kg i.g.) was administered daily for 3 days prior to ischemia. (A and B) Serum levels of Fe²⁺ and GSH. (C) Representative Perl’s staining in myocardial tissues. Scale bar = 50 µm. (D) Representative mitochondrial ultrastructure images under transmission electron microscopy. Scale bar = 2 µm. Data are shown as mean ± SD (n = 4‒5). *P < 0.05, **P < 0.01, ***P < 0.001.