Table 1. The 2 x 2 contingency table used for the computation of disproportionality metrics.

AE: adverse event; TNF: tumor necrosis factor

a is the number of adverse drug event reports that report pancreatitis associated with TNF inhibitor use, b is the number of reports that report other AEs associated with TNF inhibitor use, c is the number of reports that report pancreatitis associated with other drugs, and d is the number of other AEs (besides pancreatitis) associated with other drugs (besides TNF inhibitors).

	AE of interest	All other AEs	Total
Drug of interest	a	b	a+b
All other drugs	c	d	c+d
Total	a+c	b+d	N = a+b+c+d