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. 2024 Dec 9;15:1466208. doi: 10.3389/fphar.2024.1466208

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Copyright © 2024 Wang, Fan, Wei, Chai, Li, Gao, Liu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Z-LIG/CGA exerted cardioprotective effects by modulating cardiac macrophage polarization. (A) Gating strategy for detecting the macrophages through flow cytometry. (B–E) Changes in cardiac macrophages on 3 days post-MI. Representative image of flow cytometry (B). Proportions of M1 (C) and M2 (D), and M1/M2 ratio (E) in mice of each group. (F) Counts of macrophages in mice of each group on 3 days post-MI (per 100,000 Live Cells). (G–J) Changes in cardiac macrophages on 7 days post-MI. Representative image of flow cytometry (G). Proportions of M1 (H) and M2 (I), and the M1/M2 ratio (J) in mice of each group. (K) Counts of macrophages in mice of each group on 7 days post-MI (per 100,000 Live Cells). Data are expressed as mean ± SD (n = 5). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. Control group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Model group. +P < 0.05, ++P < 0.01, +++P < 0.001 vs. ZC group.