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. 2024 Dec 9;15:1466208. doi: 10.3389/fphar.2024.1466208

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Copyright © 2024 Wang, Fan, Wei, Chai, Li, Gao, Liu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of combinations with potential synergistic or antagonistic effects. (A–D) Validation of Z-LIG/CGA combination: (A) Inhibition rate of LDH in H9c2 cell supernatant by Z-LIG/CGA combination at 25 doses (numbers in boxes), (B) The visualization diagram of LDH inhibition rate and ZIP score of Z-LIG/CGA combination, (C) Comparison of inhibition rates of LDH by Z-LIG/CGA combination and single administrations at four doses, (D) CI values calculation based on Chou Talalay method at four doses. (E–H) Validation of Z-LIG/CFA combination: (E) Inhibition rate of LDH in H9c2 cell supernatant by Z-LIG/CFA combination at 25 doses (numbers in boxes), (F) The visualization diagram of LDH inhibition rate and ZIP score of Z-LIG/CFA combination, (G) Comparison of inhibition rates of LDH by Z-LIG/CFA combination and single administrations at four doses, (H) CI values calculation based on Chou Talalay method at four doses.